NP_004343.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cerebellin-1
NCBI Official Synonym Full Names
cerebellin 1 precursor
NCBI Protein Information
cerebellin-1; precerebellin
UniProt Protein Name
Cerebellin-1
UniProt Synonym Protein Names
PrecerebellinCleaved into the following 2 chains:Cerebellin; CER; [des-Ser1]-cerebellin
UniProt Synonym Gene Names
UniProt Entry Name
CBLN1_HUMAN
NCBI Summary for CBLN1
This gene encodes a cerebellum-specific precursor protein, precerebellin, with similarity to the globular (non-collagen-like) domain of complement component C1qB. Precerebellin is processed to give rise to several derivatives, including the hexadecapeptide, cerebellin, which is highly enriched in postsynaptic structures of Purkinje cells. Cerebellin has also been found in human and rat adrenals, where it has been shown to enhance the secretory activity of this gland. [provided by RefSeq, Aug 2008]
UniProt Comments for CBLN1
CBLN1: Cerebellin-1 is required for synapse integrity and synaptic plasticity. Required for the ER export and secretion of CBLN3.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 16q12.1
Cellular Component: postsynaptic membrane; extracellular region; cell junction
Molecular Function: protein homodimerization activity
Biological Process: heterophilic cell adhesion; positive regulation of synaptogenesis; nervous system development; synaptic transmission; protein secretion; cerebellar granule cell differentiation
Research Articles on CBLN1
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Products associated with CBLN1 antigen
Diseases associated with CBLN1 antigen
Organs/Tissues associated with CBLN1 antigen
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