NP_612511.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
monoglyceride lipase
NCBI Official Synonym Full Names
monoglyceride lipase
NCBI Official Synonym Symbols
NCBI Protein Information
monoglyceride lipase; MGL; monoacylglycerol lipase
UniProt Protein Name
Monoglyceride lipase
UniProt Synonym Protein Names
Monoacylglycerol lipase; MAGL
UniProt Synonym Gene Names
UniProt Entry Name
MGLL_RAT
NCBI Summary for Mgll
serine hydrolase that converts monoglycerides to fatty acid and glycerol; may play a role in retrograde signaling at central synapses and other forms of short-range neuronal communication [RGD, Feb 2006]
UniProt Comments for Mgll
MGLL: Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth. Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family.
Protein type: Phospholipase; EC 3.1.1.23; Lipid Metabolism - glycerolipid
Cellular Component: nucleoplasm; extrinsic to membrane; axon; lipid particle; synapse; cytosol
Molecular Function: protein homodimerization activity; hydrolase activity; acylglycerol lipase activity; lipid binding
Biological Process: triacylglycerol catabolic process; regulation of inflammatory response; regulation of signal transduction; arachidonic acid metabolic process; regulation of sensory perception of pain; regulation of axon extension; fatty acid biosynthetic process; acylglycerol catabolic process
Research Articles on Mgll
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Pathways associated with Mgll antigen
Diseases associated with Mgll antigen
Organs/Tissues associated with Mgll antigen
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