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MAOB assay kit :: Monoamine Oxidase B (MAO-B) Assay Kit

Scan QR to view Datasheet Catalog #    MBS841794
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
100 Assays  /  $595 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Monoamine Oxidase B (MAO-B) (MAOB), Assay Kit

 Also Known As   

Monoamine Oxidase B (MAO-B) Inhibitor Screening Kit (Fluorometric)

 Product Gene Name   

MAOB assay kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    309860
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 Detection Method    Fluorescence (Ex/Em = 535/587 nm)
 Features & Benefits    Rapid & sensitive
High-throughput assay to screen/study/characterize potential inhibitors of monoamine oxidase B
Includes Inhibitor Control [Selegiline]
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 Preparation and Storage    At -20 degree C
Shelf Life: 12 months
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of MAOB assay kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for MAOB assay kit

   Product Information: Monoamine Oxidase B (MAO-B) Inhibitor Screening Kit (Fluorometric): Rapid, sensitive & high-throughput assay for screening/characterizing/studying potential inhibitors of MAO B. Includes Inhibitor Control [Selegiline]. 100 assays

Background: Monoamine oxidases (MAO, EC 1.4.3.4) are a family of enzymes that can oxidize a wide variety of endogenous primary amines. Two isoforms, MAO-A and MAO-B, have been identified based on their substrate, inhibitor specificity, and tissue localization. MAO-B can oxidize primary amines, but its list of specific substrates (i.e. benzylamine, phenylethylamine) is more limited compared to MAO-A. MAO-B is a mitochondrial-bound enzyme that is ubiquitously expressed throughout the brain and other tissues. It has been investigated in numerous studies including Parkinson's disease, Alzheimer's, and tobacco addiction. Specific MAO-B inhibitors such as selegiline, & rasagiline have been used to treat Parkinson's patients, but their benefits are considered rather modest. MyBioSource's MAO-B Inhibitor Screening Kit offers a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of MAO-B inhibitors. The assay is based on the fluorometric detection of H2O2, one of the byproducts generated during the oxidative deamination of MAO substrate.

Summary: Detection method: Fluorescence (Ex/Em = 535/587 nm)
Application: Screening/studying/characterizing MAO-B inhibitors
 Product Categories/Family for MAOB assay kit    Neuroscience;; Assay Kits; Metabolism Assays; Other Metabolism-Related Assays; Metabolism Assays; Metabolism Assays (A-Z)
 Application Notes for MAOB assay kit    Screening/studying/characterizing MAO-B inhibitors
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 Typical Testing Data/Standard Curve (for reference only) of MAOB assay kit    MAOB assay kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS841794. Click to request current manual
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NCBI/Uniprot data below describe general gene information for MAOB. It may not necessarily be applicable to this product.
 NCBI GI #    398415
 NCBI GeneID    4129
 NCBI Accession #    AAB27229.1 [Other Products]
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 UniProt Secondary Accession #    Q7Z6S2; B2R6R3; B7Z5H3; D3DWC3 [Other Products]
 UniProt Related Accession #    P27338 [Other Products]
 Molecular Weight    46,539 Da [Similar Products]
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 NCBI Official Full Name    monoamine oxidase B, partial
 NCBI Official Synonym Full Names    monoamine oxidase B
 NCBI Official Symbol    MAOB [Similar Products]
 NCBI Protein Information    amine oxidase [flavin-containing] B
 UniProt Protein Name    Amine oxidase [flavin-containing] B
 UniProt Synonym Protein Names   
Monoamine oxidase type B; MAO-B
 Protein Family    Amine oxidase
 UniProt Gene Name    MAOB [Similar Products]
 UniProt Synonym Gene Names    MAO-B [Similar Products]
 UniProt Entry Name    AOFB_HUMAN
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 NCBI Summary for MAOB    The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MAOB    MAOB: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. Belongs to the flavin monoamine oxidase family.

Protein type: Amino Acid Metabolism - arginine and proline; EC 1.4.3.4; Amino Acid Metabolism - tyrosine; Mitochondrial; Amino Acid Metabolism - histidine; Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - phenylalanine; Oxidoreductase; Membrane protein, integral; Xenobiotic Metabolism - drug metabolism - cytochrome P450

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: mitochondrial envelope; mitochondrial outer membrane; mitochondrion; mitochondrial inner membrane; integral to membrane

Molecular Function: amine oxidase activity; protein homodimerization activity; electron carrier activity; FAD binding

Biological Process: response to drug; dopamine catabolic process; response to toxin; response to lipopolysaccharide; positive regulation of dopamine metabolic process; negative regulation of serotonin secretion; response to selenium ion; response to ethanol; substantia nigra development; xenobiotic metabolic process; hydrogen peroxide biosynthetic process; response to corticosterone stimulus; response to aluminum ion
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 Research Articles on MAOB    1. Data (including data from molecular dynamics simulation studies) suggest that the protonation state of the active site residue Lys296 in monoamine oxidase B does not have influence on the hydride transfer reaction in the metabolism of dopamine.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MAOB assay kitDiseases associated with MAOB assay kit
 Reference Product  PubMed Publications
 COMT assay kit  >32 publications with MAOB and COMT
 DDC assay kit  >6 publications with MAOB and DDC
 DBH assay kit  >5 publications with MAOB and DBH
 CYP2D6 assay kit  >4 publications with MAOB and CYP2D6
 PNMT assay kit  >1 publications with MAOB and PNMT
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >69 publications with MAOB and Mental Disorders
 Parkinsonian Disorders Antibodies  >43 publications with MAOB and Parkinsonian Disorders
 Parkinson Disease Antibodies  >43 publications with MAOB and Parkinson Disease
 Neurobehavioral Manifestations Antibodies  >16 publications with MAOB and Neurobehavioral Manifestations
 Schizophrenia Antibodies  >15 publications with MAOB and Schizophrenia
 Alzheimer Disease Antibodies  >6 publications with MAOB and Alzheimer Disease
 Autistic Disorder Antibodies  >6 publications with MAOB and Autistic Disorder
 Depressive Disorder Antibodies  >5 publications with MAOB and Depressive Disorder
 Learning Disorders Antibodies  >4 publications with MAOB and Learning Disorders
 Hallucinations Antibodies  >3 publications with MAOB and Hallucinations
Organs/Tissues associated with MAOB assay kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >65 publications with MAOB and Brain
 Nerve Antibodies  >15 publications with MAOB and Nerve
 Liver Antibodies  >9 publications with MAOB and Liver
 Eye Antibodies  >7 publications with MAOB and Eye
 Muscle Antibodies  >6 publications with MAOB and Muscle
 Adrenal Gland Antibodies  >5 publications with MAOB and Adrenal Gland
 Kidney Antibodies  >4 publications with MAOB and Kidney
 Pituitary Gland Antibodies  >2 publications with MAOB and Pituitary Gland
 Thyroid Antibodies  >2 publications with MAOB and Thyroid
 Skin Antibodies  >2 publications with MAOB and Skin
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