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TSHR assay system :: Thyroid Stimulating Hormone Receptor Assay System

Scan QR to view Datasheet Catalog #    MBS433661 TSHR assay system
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 Product Name   

Thyroid Stimulating Hormone Receptor (TSHR), Assay System

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 Also Known As   

Thyroid Stimulating Hormone Receptor (TSHR) ACTOne Stable Cell Line

 Product Synonym Names    Thyroid Stimulating Hormone Receptor (TSHR) ACTOneTM Stable Cell Line
 Product Gene Name   

TSHR assay system

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS433661 Technical Datasheet    Technical Datasheet PDF
 OMIM    275200
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 Preparation and Storage    Product is shipped on dry ice. Storage: Remove the frozen cells from the dry ice packaging and immediately place the cells at a temperature below -130 degrees C preferably in liquid nitrogen vapor, until ready for use.
 Other Notes    Small volumes of TSHR assay system vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TSHR assay system

   Background/Introduction: TSHR is a member of the G protein-coupled receptor superfamily of integral membrane proteins and is coupled to the Gs protein. Upon binding circulating thyrotropin, a G-protein signal cascade activates adenylyl cyclase and intercellular levels of cAMP rise. cAMP activates all functional aspects of the thyroid cell, including iodine pumping; thyroglobulin synthesis, iodination, endocytosis and proteolysis; thyroid peroxidase activity; and hormone release.
 Product Categories/Family for TSHR assay system    Cell Based GPCR-PDE Compound Assay System; ACTOne Assay on G-Protein Coupled Receptors (GPCRs)
 Application Notes for TSHR assay system    cAMP dependent human TSHR cell-based assay; cell-based high-throughput screening of human TSHR inhibitors
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Sample Manual Insert of MBS433661. Click to request current manual
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NCBI/Uniprot data below describe general gene information for TSHR. It may not necessarily be applicable to this product.
 NCBI GI #    38016895
 NCBI GeneID    7253
 NCBI Accession #    AAR07906.1 [Other Products]
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 UniProt Secondary Accession #    Q16503; Q8TB90; Q96GT6; Q9P1V4; Q9ULA3; Q9UPH3; A0PJU7; F5GYU5; G3V2A9 [Other Products]
 UniProt Related Accession #    P16473 [Other Products]
 Molecular Weight    30,800 Da
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 NCBI Official Full Name    thyroid stimulating hormone receptor
 NCBI Official Synonym Full Names    thyroid stimulating hormone receptor
 NCBI Official Symbol    TSHR [Similar Products]
 NCBI Official Synonym Symbols   
LGR3; CHNG1; hTSHR-I
[Similar Products]
 NCBI Protein Information    thyrotropin receptor; seven transmembrane helix receptor; thyroid stimulating hormone receptor, isoform 2; thyrotropin receptor-I, hTSHR-I
 UniProt Protein Name    Thyrotropin receptor
 UniProt Synonym Protein Names   
Thyroid-stimulating hormone receptor; TSH-R
 Protein Family    Thyrotropin receptor
 UniProt Gene Name    TSHR [Similar Products]
 UniProt Entry Name    TSHR_HUMAN
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 NCBI Summary for TSHR    The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
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 UniProt Comments for TSHR    TSHR: Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5). Defects in TSHR are found in patients affected by hyperthyroidism with different etiologies. Somatic, constitutively activating TSHR mutations and/or constitutively activating G(s)alpha mutations have been identified in toxic thyroid nodules (TTNs) that are the predominant cause of hyperthyroidism in iodine deficient areas. These mutations lead to TSH independent activation of the cAMP cascade resulting in thyroid growth and hormone production. TSHR mutations are found in autonomously functioning thyroid nodules (AFTN), toxic multinodular goiter (TMNG) and hyperfunctioning thyroid adenomas (HTA). TMNG encompasses a spectrum of different clinical entities, ranging from a single hyperfunctioning nodule within an enlarged thyroid, to multiple hyperfunctioning areas scattered throughout the gland. HTA are discrete encapsulated neoplasms characterized by TSH- independent autonomous growth, hypersecretion of thyroid hormones, and TSH suppression. Defects in TSHR are also a cause of thyroid neoplasms (papillary and follicular cancers). Autoantibodies against TSHR are directly responsible for the pathogenesis and hyperthyroidism of Graves disease. Antibody interaction with TSHR results in an uncontrolled receptor stimulation. Defects in TSHR are the cause of congenital hypothyroidism non-goitrous type 1 (CHNG1); also known as congenital hypothyroidism due to TSH resistance. CHNG1 is a non-autoimmune condition characterized by resistance to thyroid- stimulating hormone (TSH) leading to increased levels of plasma TSH and low levels of thyroid hormone. CHNG1 presents variable severity depending on the completeness of the defect. Most patients are euthyroid and asymptomatic, with a normal sized thyroid gland. Only a subset of patients develop hypothyroidism and present a hypoplastic thyroid gland. Defects in TSHR are the cause of familial gestational hyperthyroidism (HTFG). HTFG is a condition characterized by abnormally high levels of serum thyroid hormones occurring during early pregnancy. Defects in TSHR are the cause of hyperthyroidism non- autoimmune (HTNA). It is a condition characterized by abnormally high levels of serum thyroid hormones, thyroid hyperplasia, goiter and lack of anti-thyroid antibodies. Typical features of Graves disease such as exophthalmia, myxedema, antibodies anti-TSH receptor and lymphocytic infiltration of the thyroid gland are absent. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 14q31

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: protein binding; thyroid-stimulating hormone receptor activity

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein coupled receptor protein signaling pathway; cell-cell signaling; positive regulation of cell proliferation

Disease: Hyperthyroidism, Nonautoimmune; Hypothyroidism, Congenital, Nongoitrous, 1; Hyperthyroidism, Familial Gestational
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 Research Articles on TSHR    1. study reports a large deletion of the TSHR gene in two siblings with congenital hypothyroidism coming from a consanguineous Turkish family
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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