View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Add To Compare List AAL-993 biochemical Catalog # MBS842171 Unit / Price DISCONTINUEDClick here to view our similar product(s) OR click here to contact our technical support team for suitable replacement. Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name AAL-993, Biochemical Full Product Name AAL-993 Product Synonym Names 2-((4-Pyridyl)methyl)amino-N-(3-(trifluoromethyl)phenyl)benzamide Product Gene Name AAL-993 biochemical[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Purity/Purification >=98% by TLC Form/Format Appearance: Light yellow solid CAS Number 269390-77-4 Structure Available? Y Salt Form No Cell-Permeable? Yes PubChem CID 6398883 Solubility/Reconstitution Instructions DMSO (>25 mg/ml) or EtOH (~15 mg/ml) SMILES C1=CC=C(C(=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NCC3=CC=NC=C3 InChi InChI=1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27) InChi Key BLAFVGLBBOPRLP-UHFFFAOYSA-N Handling Protect from air and light Preparation and Storage At -20 degree CShelf Life: 36 months Other Notes Small volumes of AAL-993 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for AAL-993 biochemical Background: AAL-993 is a potent, selective and cell-permeable inhibitor of VEGFR-1 (IC?? = 130 nM), VEGFR-2 (IC?? = 23 nM) and VEGFR-3 (IC?? = 18nM). At higher concentrations it inhibits PDGFR (640 nM), c-Kit (236 nM) and CSF-1R (380 nM). Inactive at other kinases such as EGFR, FGFR-1, CDK-1, Tie-2, c-Met, IGF-1R, c-Src and c-Abl. X-ray crystal studies on AAL-993 complexed to the catalytic domain of diphosphorylated VEGFR- 2 indicates that it binds to an inactive conformation of the protein. AAL-993 inhibits VEGF-induced angiogenesis (mouse model). Product Categories/Family for AAL-993 biochemical Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase InhibitorsBiochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase InhibitorsBiochemicals; Biochemicals (A-Z) Structure of AAL-993 biochemical TOP Molecular Weight 371.36 TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP