View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Add To Compare List Aftin-4 Biochemical Catalog # MBS842258 Unit / Price DISCONTINUEDClick here to view our similar product(s) OR click here to contact our technical support team for suitable replacement. Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Aftin-4, Biochemical Full Product Name Aftin-4 Product Synonym Names N6-Methyl-(R)-roscovitine; Amyloid-beta Forty-Two Inducer 4 Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Purity/Purification >=98% by NMR Form/Format Appearance: White to off-white solid CAS Number 866893-90-5 Structure Available? Y Salt Form No Cell-Permeable? Yes Solubility/Reconstitution Instructions DMSO or EtOH SMILES CC[C@H](CO)NC1=NC(N(C)CC2=CC=CC=C2)=C3C(N(C(C)C)C=N3)=N1 InChi InChI=1S/C20H28N6O/c1-5-16(12-27)22-20-23-18(25(4)11-15-9-7-6-8-10-15)17-19(24-20)26(13-21-17)14(2)3/h6-10,13-14,16,27H,5,11-12H2,1-4H3,(H,22,23,24)/t16-/m1/s1 InChi Key YPYWONAECUVKHY-MRXNPFEDSA-N Handling Protect from air and light Preparation and Storage At -20 degree CShelf Life: 24 months Other Notes Small volumes of Aftin-4 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for Aftin-4 biochemical Background: A Roscovitine-related purine derivative that selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Abeta42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Product Categories/Family for Aftin-4 biochemical Biochemicals; Other Biochemicals and Biochemicals; Biochemicals (A-Z) Structure of Aftin-4 biochemical TOP Molecular Weight 368.48[Similar Products] TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP