View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Add To Compare List Galiellactone Biochemical Catalog # MBS843068 Unit / Price DISCONTINUEDClick here to view our similar product(s) OR click here to contact our technical support team for suitable replacement. Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Galiellactone, Biochemical Full Product Name Galiellactone Product Synonym Names (7bS)-5,5aR,6,7,7aR,7b-hexahydro-7b-hydroxy-4S-methyl-indeno[1,7-bc]furan-2(4H)-one; NSC645020; NSC-645020 Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Purity/Purification >95% Form/Format Appearance: A white lyophilized solid CAS Number 133613-71-5 Structure Available? Y Salt Form No Cell-Permeable? Yes PubChem CID 6711856 Solubility/Reconstitution Instructions DMSO SMILES CC1CC2CCC3C2(C(=C1)C(=O)O3)O InChi InChI=1S/C11H14O3/c1-6-4-7-2-3-9-11(7,13)8(5-6)10(12)14-9/h5-7,9,13H,2-4H2,1H3/t6-,7+,9+,11-/m1/s1 InChi Key SOIISBQQYAGDKM-VFYMIVFZSA-N Handling Protect from air and light Preparation and Storage At -20 degree CShelf Life: 36 months Other Notes Small volumes of Galiellactone biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for Galiellactone biochemical Background: Galiellalactone is a fungal metabolite that inhibits IL-6-mediated JAK/STAT signal transduction in HepG2 cells (IC?? = 0.25-0.5 muM). The selectivity of this compound is achieved by its ability to block the binding of activated STAT3 dimers to their DNA binding sites without affecting phosphorylation of the STAT3 transcription factor. At 10-50 muM, galiellalactone exhibits dose-dependent growth inhibitory effects on prostate cancer stem cell-like cells expressing active STAT3, suggesting it may be a useful therapeutic approach to control JAK/STAT signaling. Product Categories/Family for Galiellactone biochemical Enzyme Inhibitors; Stat Inhibitors Biochemicals; Enzyme Inhibitors; Stat Inhibitors Diabetes; Obesity & Metabolic Syndrome; Signaling Pathways in Diabetes and Obesity; JAK/Stat Signaling; Stat Inhibitors Signaling Pathways; JAK/Stat Signaling; Stat Inhibi Structure of Galiellactone biochemical TOP Molecular Weight 194.23[Similar Products] TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP