View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Add To Compare List JAK Inhibitor, Pyridone 6 Biochemical Catalog # MBS842591 Unit / Price DISCONTINUEDClick here to view our similar product(s) OR click here to contact our technical support team for suitable replacement. Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name JAK Inhibitor, Pyridone 6, Biochemical Full Product Name JAK Inhibitor, Pyridone 6 Product Synonym Names 2-(1,1-Dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[h]imidazo[4,5-f]isoquinolin-7-one; Pyridone 6; CMP 6 Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Purity/Purification >=97% by HPLC Form/Format Appearance: Off-white solid CAS Number 457081-03-7 Structure Available? Yes Salt Form No Cell-Permeable? Yes MDL Number MFCD17019334 PubChem CID 5494425 Solubility/Reconstitution Instructions DMSO (5 mg/ml) SMILES CC(C)(C)C1=NC2=C(N1)C3=C(C=C(C=C3)F)C4=C2C=CNC4=O InChi InChI=1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22) InChi Key VNDWQCSOSCCWIP-UHFFFAOYSA-N Handling Protect from air and light Preparation and Storage At -20 degree CShelf Life: 24 months Other Notes Small volumes of JAK Inhibitor, Pyridone 6 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for JAK Inhibitor, Pyridone 6 biochemical Background: Cell-permeable. JAK Inhibitor, Pyridone 6 is a potent, reversible, ATP-competitive JAK inhibitor. It inhibits JAK1, 2, and 3 with IC?? values of 15, 1, and 5 nM, respectively. Displays signi?cantly weaker affinities (IC??s = 130 nM - > 10 muM) for other protein tyrosine kinases. It was shown to block IL-2 and IL-4-dependent proliferation of mouse T-cell lymphoma cells with IC?? values of 50-100 nM. Product Categories/Family for JAK Inhibitor, Pyridone 6 biochemical Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase Inhibitors and Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase Inhibitors and Signaling Pathways; JAK/Stat Signaling; JAK Inhibitors and Diabetes; Ob Structure of JAK Inhibitor, Pyridone 6 biochemical TOP Molecular Weight 309.3[Similar Products] TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP