View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Add To Compare List JH-II-127 biochemical Catalog # MBS845811 Unit / Price DISCONTINUEDClick here to view our similar product(s) OR click here to contact our technical support team for suitable replacement. Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name JH-II-127, Biochemical Full Product Name JH-II-127 Product Synonym Names 4- ( (5-chloro-4- (methylamino)-7H-pyrrolo[2; 3-d]pyrimidin-2-yl) amino)-3-methoxyphenyl) (morpholino) methanone Product Gene Name JH-II-127 biochemical[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Purity/Purification >=98% by HPLC Form/Format Crystalline solid Salt Form No Molecular Formula C19H21ClN6O2 CAS Number 1700693-08-8 Cell-Permeable Yes Reconstitution DMSO (>20 mg/ml) Preparation and Storage Store at -20 degree C for 36 months.Protect from air and light. Other Notes Small volumes of JH-II-127 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for JH-II-127 biochemical JH-II-127 is a highly potent; selective; and cell-permeable LRRK2 inhibitor; with IC50 of 6.6 nM; 2.2 nM; 47.7 nM for LRRK2-wild-type; LRRK2-G2019S; LRRK2-A2016T. JH-II-127 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 muM in a variety of cell types and is capable of inhibiting Ser935 phosphorylation in mouse brain following oral delivery of doses as low as 30 mg/kg. Molecular Weight 416.87 TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP