View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Add To Compare List UNC0646 biochemical Catalog # MBS842255 Unit / Price DISCONTINUEDClick here to view our similar product(s) OR click here to contact our technical support team for suitable replacement. Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name UNC0646, Biochemical Full Product Name UNC0646 Product Synonym Names N-(1-cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine Product Gene Name UNC0646 biochemical[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Purity/Purification >98% by HPLC Form/Format Appearance: Pale yellow solid CAS Number 1320288-17-2 Structure Available? Y Salt Form No Cell-Permeable? Yes PubChem CID 53315882 Solubility/Reconstitution Instructions DMSO (~50 mg/ml) or EtOH (~50 mg/ml) SMILES CC(C)N1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)C5CCCCC5)OC)OCCCN6CCCCC6 InChi InChI=1S/C36H59N7O2/c1-28(2)41-19-10-20-43(24-23-41)36-38-32-27-34(45-25-11-18-40-16-8-5-9-17-40)33(44-3)26-31(32)35(39-36)37-29-14-21-42(22-15-29)30-12-6-4-7-13-30/h26-30H,4-25H2,1-3H3,(H,37,38,39) InChi Key OUKWLRHRXOPODD-UHFFFAOYSA-N Handling Protect from air and light Preparation and Storage At -20 degree CShelf Life: 36 months Other Notes Small volumes of UNC0646 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for UNC0646 biochemical Background: UNC0646 is a potent and selective inhibitor of protein lysine methyltransferases G9a and GLP activities in vitro (IC??s = 6 and 15 nM, respectively) ; inhibits G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC?? = 26 nM). It is highly selective for G9a/GLP over several other protein lysine and arginine methyltransferases.UNC0646 potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 line. Product Categories/Family for UNC0646 biochemical Enzyme Inhibitors; Methyltransferase Inhibitors and Biochemicals; Enzyme Inhibitors; Methyltransferase Inhibitors and Epigenetics; Writer Enzymes; Protein Lysine Methyltransferases (PKMTs); PKMT Inhibitors and Biochemicals; Biochemicals (A-Z) Structure of UNC0646 biochemical TOP Molecular Weight 621.9 TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP