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XL019 biochemical

Scan QR to view Datasheet Catalog #    MBS843170
Structure
Unit / Price
5 mg  /  $155 +1 FREE 8GB USB
25 mg  /  $430 +1 FREE 8GB USB
 
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 Product Name   

XL019, Biochemical

 Also Known As   

XL019

 Product Synonym Names    (S)-N-(4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)phenyl)pyrrolidine-2-carboxamide  
 Product Gene Name   

XL019 biochemical

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Purity/Purification    >98% by HPLC
 Form/Format    Appearance: Light yellow to light brown solid
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 CAS Number    945755-56-6
 Structure Available?    Y
 Salt Form    No
 Cell-Permeable?    Yes
 PubChem CID    57990869
 Solubility/Reconstitution Instructions    DMSO (~ 15 mg/ml)
 SMILES    C1CC(NC1)C(=O)NC2=CC=C(C=C2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5
 InChi    InChI=1S/C25H28N6O2/c32-24(23-2-1-12-26-23)28-19-5-3-18(4-6-19)22-11-13-27-25(30-22)29-20-7-9-21(10-8-20)31-14-16-33-17-15-31/h3-11,13,23,26H,1-2,12,14-17H2,(H,28,32)(H,27,29,30)/t23-/m0/s1
 InChi Key    ISOCDPQFIXDIMS-QHCPKHFHSA-N
 Handling    Protect from air and light
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 Preparation and Storage    At -20 degree C
Shelf Life: 36 months
 Other Notes    Small volumes of XL019 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for XL019 biochemical

   Background: XL019 is a potent, highly selective and reversible JAK2 inhibitor (IC?? = 2.2 nM). Inhibits JAK1 (IC?? = 134.3 nM), JAK3 (IC50 = 214.2 nM) and TYK2 (IC?? = 348.3 nM) at higher concentrations. XL019 displays significant dose-dependent pharmacodynamic and antitumor effect in a mouse xenograft model.
 Product Categories/Family for XL019 biochemical    Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase Inhibitors and Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase Inhibitors and Epigenetics; Writer Enzymes; Kinases; Kinase Inhibitors; JAK2 Inhibitor
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 Structure of XL019 biochemical    XL019 biochemical Structure image
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 Molecular Weight    444.53
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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