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YWHAE blocking peptide :: 14-3-3 epsilon Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS822465 YWHAE blocking peptide
Unit / Price
1 mg  /  $160 +1 FREE 8GB USB
5 mg  /  $305 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

14-3-3 epsilon (YWHAE), Blocking Peptide

 Also Known As   

14-3-3 epsilon Blocking Peptide

 Product Synonym Names    14-3-3 protein epsilon; 14-3-3E
 Product Gene Name   

YWHAE blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    14-3-3 epsilon peptide (MBS822465) is used for blocking the activity of 14-3-3 epsilon antibody (MBS820834)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605066
 3D Structure    ModBase 3D Structure for P62258
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 Host    Synthetic
 Species Reactivity    Human, Mouse, Rat, Bovine, Chicken, Monkey, Sheep, Zebrafish
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 Purity/Purification    >85%
 Form/Format    Lyophilized powder
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 Quality Control    The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Other Notes    Small volumes of YWHAE blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for YWHAE blocking peptide

   The peptide is used to block Anti-14-3-3 epsilon Antibody reactivity.
 Applications Tested/Suitable for YWHAE blocking peptide   

Blocking (BL)

 Application Notes for YWHAE blocking peptide    Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
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NCBI/Uniprot data below describe general gene information for YWHAE. It may not necessarily be applicable to this product.
 NCBI GI #    5803225
 NCBI GeneID    7531
 NCBI Accession #    NP_006752.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006761.4 [Other Products]
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 UniProt Primary Accession #    P62258 [Other Products]
 UniProt Secondary Accession #    P29360; P42655; Q4VJB6; Q53XZ5; Q63631; Q7M4R4; B3KY71; D3DTH5 [Other Products]
 UniProt Related Accession #    P62258 [Other Products]
 Molecular Weight    26,504 Da
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 NCBI Official Full Name    14-3-3 protein epsilon
 NCBI Official Synonym Full Names    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
 NCBI Official Symbol    YWHAE [Similar Products]
 NCBI Official Synonym Symbols   
MDS; HEL2; MDCR; KCIP-1; 14-3-3E
[Similar Products]
 NCBI Protein Information    14-3-3 protein epsilon; 14-3-3 epsilon; epididymis luminal protein 2; protein kinase C inhibitor protein-1; mitochondrial import stimulation factor L subunit; tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
 UniProt Protein Name    14-3-3 protein epsilon
 Protein Family    14-3-3 protein
 UniProt Gene Name    YWHAE [Similar Products]
 UniProt Synonym Gene Names    14-3-3E [Similar Products]
 UniProt Entry Name    1433E_HUMAN
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 NCBI Summary for YWHAE    This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
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 UniProt Comments for YWHAE    14-3-3 epsilon: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: kinesin complex; cytoplasmic vesicle membrane; focal adhesion; membrane; mitochondrion; axon; melanosome; cytosol

Molecular Function: protein domain specific binding; protein binding; potassium channel regulator activity; enzyme binding; protein heterodimerization activity; histone deacetylase binding; phosphoprotein binding; phosphoserine binding

Biological Process: substantia nigra development; viral reproduction; nerve growth factor receptor signaling pathway; apoptosis; organelle organization and biogenesis; hippocampus development; neuron migration; mitotic cell cycle; cerebral cortex development; regulation of caspase activity; G2/M transition of mitotic cell cycle; regulation of the rate of heart contraction by hormone; protein targeting

Disease: Miller-dieker Lissencephaly Syndrome
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 Research Articles on YWHAE    1. Data show that two isoforms of the 14-3-3 family, 14-3-3epsilon and 14-3-3 gamma, can stabilize Cdt2 independent of each other when overexpressed.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with YWHAE blocking peptidePathways associated with YWHAE blocking peptide
 Reference Product  PubMed Publications
 BAD blocking peptide  >3 publications with YWHAE and BAD
 YWHAZ blocking peptide  >3 publications with YWHAE and YWHAZ
 CDC25B blocking peptide  >3 publications with YWHAE and CDC25B
 BRAF blocking peptide  >1 publications with YWHAE and BRAF
 MAP2K1 blocking peptide  >1 publications with YWHAE and MAP2K1
 RAF1 blocking peptide  >1 publications with YWHAE and RAF1
 Products by Pathway  Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with YWHAE blocking peptideOrgans/Tissues associated with YWHAE blocking peptide
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >8 publications with YWHAE and Brain Diseases
 Classical Lissencephalies and Subcortical Band Heterotopias Antibodies  >8 publications with YWHAE and Classical Lissencephalies and Subcortical Band Heterotopias
 Seizures Antibodies  >6 publications with YWHAE and Seizures
 Cardiovascular Diseases Antibodies  >5 publications with YWHAE and Cardiovascular Diseases
 Necrosis Antibodies  >5 publications with YWHAE and Necrosis
 Heart Diseases Antibodies  >4 publications with YWHAE and Heart Diseases
 Heart Defects, Congenital Antibodies  >4 publications with YWHAE and Heart Defects, Congenital
 Adenocarcinoma Antibodies  >4 publications with YWHAE and Adenocarcinoma
 Kidney Diseases Antibodies  >3 publications with YWHAE and Kidney Diseases
 Inflammation Antibodies  >3 publications with YWHAE and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >25 publications with YWHAE and Brain
 Heart Antibodies  >8 publications with YWHAE and Heart
 Blood Antibodies  >6 publications with YWHAE and Blood
 Vascular Antibodies  >5 publications with YWHAE and Vascular
 Nerve Antibodies  >5 publications with YWHAE and Nerve
 Muscle Antibodies  >5 publications with YWHAE and Muscle
 Kidney Antibodies  >4 publications with YWHAE and Kidney
 Uterus Antibodies  >4 publications with YWHAE and Uterus
 Liver Antibodies  >3 publications with YWHAE and Liver
 Lymph Node Antibodies  >3 publications with YWHAE and Lymph Node
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