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EIF4EBP1 blocking peptide :: 4EBP1 Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS8216383 EIF4EBP1 blocking peptide
Unit / Price
1 mg  /  $195 +1 FREE 8GB USB
5 mg  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

4EBP1 (EIF4EBP1), Blocking Peptide

 Also Known As   

4EBP1 (pT69) Blocking Peptide

 Product Synonym Names    EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
 Product Gene Name   

EIF4EBP1 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    4EBP1 peptide (MBS8216383) is used for blocking the activity of 4EBP1 antibody (MBS8211963)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602223
 3D Structure    ModBase 3D Structure for Q13541
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 Host    Synthetic
 Species Reactivity    Human, Mouse, Rat, Monkey
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 Purity/Purification    >85%
 Form/Format    Lyophilized powder
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 Quality Control    The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
 Directions for Use    Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Other Notes    Small volumes of EIF4EBP1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for EIF4EBP1 blocking peptide

   The peptide is used to block Anti-4EBP1 (pT69) Antibody reactivity.
 Applications Tested/Suitable for EIF4EBP1 blocking peptide   

Blocking (BL)

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NCBI/Uniprot data below describe general gene information for EIF4EBP1. It may not necessarily be applicable to this product.
 NCBI GI #    4758258
 NCBI GeneID    1978
 NCBI Accession #    NP_004086.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004095.3 [Other Products]
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 UniProt Primary Accession #    Q13541 [Other Products]
 UniProt Secondary Accession #    Q6IBN3; B2R502; D3DSW8 [Other Products]
 UniProt Related Accession #    Q13541 [Other Products]
 Molecular Weight    12,580 Da
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 NCBI Official Full Name    eukaryotic translation initiation factor 4E-binding protein 1
 NCBI Official Synonym Full Names    eukaryotic translation initiation factor 4E binding protein 1
 NCBI Official Symbol    EIF4EBP1 [Similar Products]
 NCBI Official Synonym Symbols   
BP-1; 4EBP1; 4E-BP1; PHAS-I
[Similar Products]
 NCBI Protein Information    eukaryotic translation initiation factor 4E-binding protein 1
 UniProt Protein Name    Eukaryotic translation initiation factor 4E-binding protein 1
 UniProt Synonym Protein Names   
Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
 Protein Family    Eukaryotic translation initiation factor 4E-binding protein
 UniProt Gene Name    EIF4EBP1 [Similar Products]
 UniProt Synonym Gene Names    4E-BP1; eIF4E-binding protein 1; PHAS-I [Similar Products]
 UniProt Entry Name    4EBP1_HUMAN
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 NCBI Summary for EIF4EBP1    This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for EIF4EBP1    4E-BP1: binds to eIF4E, preventing its assembly into the EIF4F complex and inhibiting cap-dependent translation. Phosphorylation of 4E-BP1 disrupts this binding, activating cap-dependent translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the PI3 kinase pathway.

Protein type: Translation initiation; Translation

Chromosomal Location of Human Ortholog: 8p12

Cellular Component: nucleoplasm; protein complex; cytoplasm; cytosol

Molecular Function: protein binding; translation repressor activity; eukaryotic initiation factor 4E binding

Biological Process: negative regulation of translational initiation; response to ethanol; cellular protein metabolic process; TOR signaling pathway; translation; insulin receptor signaling pathway; translational initiation; gene expression; positive regulation of mitotic cell cycle; negative regulation of protein complex assembly; G1/S transition of mitotic cell cycle; lung development
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 Research Articles on EIF4EBP1    1. ShcA drives breast tumor growth and angiogenesis in vivo in a 4E-BP-dependent manner
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with EIF4EBP1 blocking peptidePathways associated with EIF4EBP1 blocking peptide
 Reference Product  PubMed Publications
 MTOR blocking peptide  >567 publications with EIF4EBP1 and MTOR
 EIF4E blocking peptide  >538 publications with EIF4EBP1 and EIF4E
 AKT1 blocking peptide  >58 publications with EIF4EBP1 and AKT1
 RPTOR blocking peptide  >34 publications with EIF4EBP1 and RPTOR
 RICTOR blocking peptide  >17 publications with EIF4EBP1 and RICTOR
 RPS6KB1 blocking peptide  >10 publications with EIF4EBP1 and RPS6KB1
 EIF4G1 blocking peptide  >10 publications with EIF4EBP1 and EIF4G1
 LRRK2 blocking peptide  >5 publications with EIF4EBP1 and LRRK2
 MLST8 blocking peptide  >5 publications with EIF4EBP1 and MLST8
 MAPKAP1 blocking peptide  >1 publications with EIF4EBP1 and MAPKAP1
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies  Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 Choline Metabolism In Cancer Pathway antibodies  Choline Metabolism In Cancer Pathway Diagram
Diseases associated with EIF4EBP1 blocking peptideOrgans/Tissues associated with EIF4EBP1 blocking peptide
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >52 publications with EIF4EBP1 and Breast Neoplasms
 Hypertrophy Antibodies  >46 publications with EIF4EBP1 and Hypertrophy
 Cardiovascular Diseases Antibodies  >40 publications with EIF4EBP1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >39 publications with EIF4EBP1 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >27 publications with EIF4EBP1 and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >26 publications with EIF4EBP1 and Neoplasms, Experimental
 Necrosis Antibodies  >25 publications with EIF4EBP1 and Necrosis
 Cell Transformation, Neoplastic Antibodies  >25 publications with EIF4EBP1 and Cell Transformation, Neoplastic
 Kidney Diseases Antibodies  >23 publications with EIF4EBP1 and Kidney Diseases
 Leukemia, Myeloid, Acute Antibodies  >18 publications with EIF4EBP1 and Leukemia, Myeloid, Acute
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >185 publications with EIF4EBP1 and Muscle
 Blood Antibodies  >134 publications with EIF4EBP1 and Blood
 Vascular Antibodies  >59 publications with EIF4EBP1 and Vascular
 Liver Antibodies  >58 publications with EIF4EBP1 and Liver
 Brain Antibodies  >52 publications with EIF4EBP1 and Brain
 Kidney Antibodies  >42 publications with EIF4EBP1 and Kidney
 Heart Antibodies  >42 publications with EIF4EBP1 and Heart
 Lung Antibodies  >41 publications with EIF4EBP1 and Lung
 Pancreas Antibodies  >25 publications with EIF4EBP1 and Pancreas
 Skin Antibodies  >21 publications with EIF4EBP1 and Skin
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