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HTR1A blocking peptide :: 5-HT1A Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS823997 HTR1A blocking peptide
Unit / Price
1 mg  /  $160 +1 FREE 8GB USB
5 mg  /  $305 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

5-HT1A (HTR1A), Blocking Peptide

 Also Known As   

5-HT1A Blocking Peptide

 Product Synonym Names    ADRB2RL1; ADRBRL1; 5-hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; G-21; Serotonin receptor 1A
 Product Gene Name   

HTR1A blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    5-HT1A peptide (MBS823997) is used for blocking the activity of 5-HT1A antibody (MBS821420)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 614674
 3D Structure    ModBase 3D Structure for P08908
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 Host    Synthetic
 Species Reactivity    Human, Rat, Rabbit
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 Purity/Purification    >85%
 Form/Format    Lyophilized powder
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 Quality Control    The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Other Notes    Small volumes of HTR1A blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for HTR1A blocking peptide

   The peptide is used to block Anti-5-HT1A Antibody reactivity.
 Applications Tested/Suitable for HTR1A blocking peptide   

Blocking (BL)

 Application Notes for HTR1A blocking peptide    Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
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NCBI/Uniprot data below describe general gene information for HTR1A. It may not necessarily be applicable to this product.
 NCBI GI #    55956923
 NCBI GeneID    3350
 NCBI Accession #    NP_000515.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000524.3 [Other Products]
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 UniProt Primary Accession #    P08908 [Other Products]
 UniProt Secondary Accession #    Q6LAE7 [Other Products]
 UniProt Related Accession #    P08908 [Other Products]
 Molecular Weight    46,107 Da
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 NCBI Official Full Name    5-hydroxytryptamine receptor 1A
 NCBI Official Synonym Full Names    5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
 NCBI Official Symbol    HTR1A [Similar Products]
 NCBI Official Synonym Symbols   
G-21; 5HT1a; PFMCD; 5-HT1A; 5-HT-1A; ADRBRL1; ADRB2RL1
[Similar Products]
 NCBI Protein Information    5-hydroxytryptamine receptor 1A; 5-HT1a receptor; guanine nucleotide-binding regulatory protein-coupled receptor
 UniProt Protein Name    5-hydroxytryptamine receptor 1A
 UniProt Synonym Protein Names   
G-21; Serotonin receptor 1A
 Protein Family    5-hydroxytryptamine receptor
 UniProt Gene Name    HTR1A [Similar Products]
 UniProt Synonym Gene Names    ADRB2RL1; ADRBRL1; 5-HT-1A; 5-HT1A [Similar Products]
 UniProt Entry Name    5HT1A_HUMAN
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 NCBI Summary for HTR1A    This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]
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 UniProt Comments for HTR1A    5-HT(1A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 5q11.2-q13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; serotonin receptor activity

Biological Process: vasoconstriction; G-protein coupled receptor protein signaling pathway; cell proliferation; behavioral fear response; serotonin receptor, adenylate cyclase inhibiting pathway; positive regulation of cell proliferation; regulation of dopamine metabolic process; regulation of serotonin secretion; regulation of hormone secretion; serotonin receptor signaling pathway; serotonin metabolic process; regulation of behavior

Disease: Periodic Fever, Menstrual Cycle-dependent
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 Research Articles on HTR1A    1. An increase in somatodendritic but not postsynaptic 5-HT1A autoreceptor functions in medication-free depressed patients leads to increased receptor function in depressed patients, compared with a cohort of controls.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HTR1A blocking peptidePathways associated with HTR1A blocking peptide
 Reference Product  PubMed Publications
 HTR1B blocking peptide  >33 publications with HTR1A and HTR1B
 HTR1D blocking peptide  >9 publications with HTR1A and HTR1D
 ADCY1 blocking peptide  >1 publications with HTR1A and ADCY1
 NPY blocking peptide  >1 publications with HTR1A and NPY
 GAL blocking peptide  >1 publications with HTR1A and GAL
 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Monoamine GPCRs Pathway antibodies  Monoamine GPCRs Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
Diseases associated with HTR1A blocking peptideOrgans/Tissues associated with HTR1A blocking peptide
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >86 publications with HTR1A and Mental Disorders
 Mood Disorders Antibodies  >49 publications with HTR1A and Mood Disorders
 Depressive Disorder Antibodies  >45 publications with HTR1A and Depressive Disorder
 Depressive Disorder, Major Antibodies  >40 publications with HTR1A and Depressive Disorder, Major
 Anxiety Disorders Antibodies  >26 publications with HTR1A and Anxiety Disorders
 Bipolar Disorder Antibodies  >10 publications with HTR1A and Bipolar Disorder
 Panic Disorder Antibodies  >8 publications with HTR1A and Panic Disorder
 Personality Disorders Antibodies  >8 publications with HTR1A and Personality Disorders
 Pain Antibodies  >4 publications with HTR1A and Pain
 Cognition Disorders Antibodies  >3 publications with HTR1A and Cognition Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >67 publications with HTR1A and Brain
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