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HTR4 blocking peptide :: 5-HT4 Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS824042 HTR4 blocking peptide
Unit / Price
1 mg  /  $160 +1 FREE 8GB USB
5 mg  /  $305 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

5-HT4 (HTR4), Blocking Peptide

 Also Known As   

5-HT4 Blocking Peptide

 Product Synonym Names    5-hydroxytryptamine receptor 4; 5-HT-4; 5-HT4; Serotonin receptor 4
 Product Gene Name   

HTR4 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    5-HT4 peptide (MBS824042) is used for blocking the activity of 5-HT4 antibody (MBS822088)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602164
 3D Structure    ModBase 3D Structure for Q13639
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 Host    Synthetic
 Species Reactivity    Human, Bovine, Pig
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 Purity/Purification    >85%
 Form/Format    Lyophilized powder
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 Quality Control    The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Other Notes    Small volumes of HTR4 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for HTR4 blocking peptide

   The peptide is used to block Anti-5-HT4 Antibody reactivity.
 Applications Tested/Suitable for HTR4 blocking peptide   

Blocking (BL)

 Application Notes for HTR4 blocking peptide    Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
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NCBI/Uniprot data below describe general gene information for HTR4. It may not necessarily be applicable to this product.
 NCBI GI #    11321563
 NCBI GeneID    3360
 NCBI Accession #    NP_000861.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000870.6 [Other Products]
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 UniProt Primary Accession #    Q13639 [Other Products]
 UniProt Secondary Accession #    Q546Q1; Q684M0; Q712M9; Q96KH9; Q96KI0; Q9H199; Q9NY73; Q9UBM6; Q9UBT4; Q9UE22; C4WYH4 [Other Products]
 UniProt Related Accession #    Q13639 [Other Products]
 Molecular Weight    46,907 Da
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 NCBI Official Full Name    5-hydroxytryptamine receptor 4 isoform b
 NCBI Official Synonym Full Names    5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
 NCBI Official Symbol    HTR4 [Similar Products]
 NCBI Official Synonym Symbols   
5-HT4; 5-HT4R
[Similar Products]
 NCBI Protein Information    5-hydroxytryptamine receptor 4; cardiac 5-HT4 receptor
 UniProt Protein Name    5-hydroxytryptamine receptor 4
 UniProt Synonym Protein Names   
Serotonin receptor 4
 Protein Family    5-hydroxytryptamine receptor
 UniProt Gene Name    HTR4 [Similar Products]
 UniProt Synonym Gene Names    5-HT-4; 5-HT4 [Similar Products]
 UniProt Entry Name    5HT4R_HUMAN
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 NCBI Summary for HTR4    This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]
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 UniProt Comments for HTR4    5-HT(4): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 5q31-q33

Cellular Component: membrane; integral to plasma membrane; cytoplasm; plasma membrane; endosome

Molecular Function: serotonin receptor activity

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein coupled receptor protein signaling pathway; synaptic transmission; positive regulation of cell proliferation; regulation of appetite; serotonin receptor signaling pathway
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 Research Articles on HTR4    1. This is the first transgenic model to study human 5-HTreceptor in the atrium ex vivo or in vivo.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with HTR4 blocking peptideDiseases associated with HTR4 blocking peptide
 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Monoamine GPCRs Pathway antibodies  Monoamine GPCRs Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >14 publications with HTR4 and Mental Disorders
 Lung Diseases Antibodies  >7 publications with HTR4 and Lung Diseases
 Schizophrenia Antibodies  >7 publications with HTR4 and Schizophrenia
 Nervous System Diseases Antibodies  >4 publications with HTR4 and Nervous System Diseases
 Inflammation Antibodies  >3 publications with HTR4 and Inflammation
 Disease Models, Animal Antibodies  >2 publications with HTR4 and Disease Models, Animal
 Heart Diseases Antibodies  >2 publications with HTR4 and Heart Diseases
 Depressive Disorder Antibodies  >1 publications with HTR4 and Depressive Disorder
Organs/Tissues associated with HTR4 blocking peptide
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >16 publications with HTR4 and Brain
 Nerve Antibodies  >3 publications with HTR4 and Nerve
 Intestine Antibodies  >3 publications with HTR4 and Intestine
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