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ABL1 blocking peptide :: ABL1 (Y393) Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS9224982 ABL1 blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABL1 (Y393), Blocking Peptide

 Also Known As   

Phospho-ABL1(Y393) Antibody Blocking peptide

 Product Synonym Names    Tyrosine-protein kinase ABL1; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150; ABL1; ABL; JTK7
 Product Gene Name   

ABL1 blocking peptide

[Similar Products]
 Product Synonym Gene Name    ABL; JTK7 [Similar Products]
 Antibody/Peptide Pairs    ABL1 (Y393) peptide (MBS9224982) is used for blocking the activity of ABL (Y412) antibody (MBS9204367)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    189980
 3D Structure    ModBase 3D Structure for P00519
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 Specificity    The synthetic peptide sequence used to generate the antibody was selected from the Center region of human ABL2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
 Form/Format    The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
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 Cellular Location    Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Note: Shuttles between the nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative stress (By similarity)
 Tissue Location    Widely expressed.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of ABL1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for ABL1 blocking peptide

   Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage- induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin- associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
NCBI/Uniprot data below describe general gene information for ABL1. It may not necessarily be applicable to this product.
 NCBI GI #    85681908
 NCBI GeneID    25
 NCBI Accession #    P00519.4 [Other Products]
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 UniProt Primary Accession #    P00519 [Other Products]
 UniProt Secondary Accession #    Q13869; Q13870; Q16133; Q17R61; Q45F09; A3KFJ3 [Other Products]
 UniProt Related Accession #    P00519 [Other Products]
 Molecular Weight    124,955 Da
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 NCBI Official Full Name    Tyrosine-protein kinase ABL1
 NCBI Official Synonym Full Names    ABL proto-oncogene 1, non-receptor tyrosine kinase
 NCBI Official Symbol    ABL1 [Similar Products]
 NCBI Official Synonym Symbols   
ABL; JTK7; p150; c-ABL; v-abl; c-ABL1; bcr/abl
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase ABL1
 UniProt Protein Name    Tyrosine-protein kinase ABL1
 UniProt Synonym Protein Names   
Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150
 Protein Family    Tyrosine-protein kinase
 UniProt Gene Name    ABL1 [Similar Products]
 UniProt Synonym Gene Names    ABL; JTK7 [Similar Products]
 UniProt Entry Name    ABL1_HUMAN
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 NCBI Summary for ABL1    This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
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 UniProt Comments for ABL1    Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
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 Research Articles on ABL1    1. Blockade of the interaction between Bcr-Abl and PTB1B by small molecule SBF-1 to overcomes imatinib-resistance of K562 cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ABL1 blocking peptidePathways associated with ABL1 blocking peptide
 Reference Product  PubMed Publications
 BCR blocking peptide  >1293 publications with ABL1 and BCR
 CRKL blocking peptide  >13 publications with ABL1 and CRKL
 RB1 blocking peptide  >10 publications with ABL1 and RB1
 GRB2 blocking peptide  >9 publications with ABL1 and GRB2
 CBL blocking peptide  >9 publications with ABL1 and CBL
 ABI1 blocking peptide  >9 publications with ABL1 and ABI1
 ATM blocking peptide  >7 publications with ABL1 and ATM
 RAD51 blocking peptide  >2 publications with ABL1 and RAD51
 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CDO In Myogenesis Pathway antibodies  CDO In Myogenesis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
Diseases associated with ABL1 blocking peptideOrgans/Tissues associated with ABL1 blocking peptide
 Disease Name  Pubmed Publications
 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies  >583 publications with ABL1 and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
 Precursor Cell Lymphoblastic Leukemia-Lymphoma Antibodies  >216 publications with ABL1 and Precursor Cell Lymphoblastic Leukemia-Lymphoma
 Cell Transformation, Neoplastic Antibodies  >81 publications with ABL1 and Cell Transformation, Neoplastic
 Carcinogenesis Antibodies  >80 publications with ABL1 and Carcinogenesis
 Anemia Antibodies  >28 publications with ABL1 and Anemia
 Disease Models, Animal Antibodies  >21 publications with ABL1 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >20 publications with ABL1 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >18 publications with ABL1 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >14 publications with ABL1 and Nervous System Diseases
 Adenocarcinoma Antibodies  >13 publications with ABL1 and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >373 publications with ABL1 and Blood
 Bone Antibodies  >230 publications with ABL1 and Bone
 Bone Marrow Antibodies  >221 publications with ABL1 and Bone Marrow
 Spleen Antibodies  >21 publications with ABL1 and Spleen
 Lung Antibodies  >18 publications with ABL1 and Lung
 Liver Antibodies  >12 publications with ABL1 and Liver
 Prostate Antibodies  >12 publications with ABL1 and Prostate
 Lymph Antibodies  >11 publications with ABL1 and Lymph
 Lymph Node Antibodies  >11 publications with ABL1 and Lymph Node
 Brain Antibodies  >11 publications with ABL1 and Brain
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