NP_942131.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
269,999 Da
NCBI Official Full Name
acetyl-CoA carboxylase 1 isoform 1
NCBI Official Synonym Full Names
acetyl-CoA carboxylase alpha
NCBI Protein Information
acetyl-CoA carboxylase 1
UniProt Protein Name
Acetyl-CoA carboxylase 1
UniProt Synonym Protein Names
ACC-alphaIncluding the following 1 domains:Biotin carboxylase (EC:6.3.4.14
UniProt Synonym Gene Names
UniProt Entry Name
ACACA_HUMAN
NCBI Summary for ACACA
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ACACA
ACC1: a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland. ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity.
Protein type: Carbohydrate Metabolism - pyruvate; Ligase; Carbohydrate Metabolism - propanoate; EC 6.4.1.2; Lipid Metabolism - fatty acid biosynthesis; EC 6.3.4.14
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: mitochondrion; cytoplasm; nucleolus; cytosol; actin cytoskeleton
Molecular Function: protein binding; acetyl-CoA carboxylase activity; metal ion binding; biotin carboxylase activity; ATP binding
Biological Process: vitamin metabolic process; acetyl-CoA metabolic process; positive regulation of cellular metabolic process; lipid homeostasis; triacylglycerol biosynthetic process; carnitine shuttle; cellular lipid metabolic process; biotin metabolic process; protein homotetramerization; multicellular organismal protein metabolic process; tissue homeostasis; energy reserve metabolic process; fatty acid biosynthetic process; water-soluble vitamin metabolic process
Disease: Acetyl-coa Carboxylase Deficiency
Research Articles on ACACA
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Products associated with ACACA blocking peptide
Pathways associated with ACACA blocking peptide
Diseases associated with ACACA blocking peptide
Organs/Tissues associated with ACACA blocking peptide
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