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ACACA blocking peptide :: ACC alpha Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS8244131 ACACA blocking peptide
Unit / Price
1 mg  /  $195 +1 FREE 8GB USB
5 mg  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACC alpha (ACACA), Blocking Peptide

 Also Known As   

ACC alpha (pS80) Blocking Peptide

 Product Synonym Names    ACAC; ACC1; ACCA; Acetyl-CoA carboxylase 1; ACC1; ACC-alpha
 Product Gene Name   

ACACA blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    ACC alpha peptide (MBS8244131) is used for blocking the activity of ACC alpha antibody (MBS8241730)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    200350
 3D Structure    ModBase 3D Structure for Q13085
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 Host    Synthetic
 Species Reactivity    Human, Mouse, Rat, Bovine, Chicken, Sheep
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 Purity/Purification    >85%
 Form/Format    Lyophilized Powder
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 Quality Control    The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Other Notes    Small volumes of ACACA blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for ACACA blocking peptide

   The peptide is used to block Anti-ACC alpha reactivity.
 Applications Tested/Suitable for ACACA blocking peptide   

Blocking (BL)

 Application Notes for ACACA blocking peptide    Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
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NCBI/Uniprot data below describe general gene information for ACACA. It may not necessarily be applicable to this product.
 NCBI GI #    118601083
 NCBI GeneID    31
 NCBI Accession #    Q13085.2 [Other Products]
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 UniProt Primary Accession #    Q13085 [Other Products]
 UniProt Secondary Accession #    Q6KEV6; Q6XDA8; Q7Z2G8; Q7Z561; Q7Z563; Q7Z564; Q86WB2; Q86WB3; B2RP68 [Other Products]
 UniProt Related Accession #    Q13085 [Other Products]
 Molecular Weight    269,999 Da
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 NCBI Official Full Name    Acetyl-CoA carboxylase 1
 NCBI Official Synonym Full Names    acetyl-CoA carboxylase alpha
 NCBI Official Symbol    ACACA [Similar Products]
 NCBI Official Synonym Symbols   
ACC; ACAC; ACC1; ACCA; ACACAD
[Similar Products]
 NCBI Protein Information    acetyl-CoA carboxylase 1
 UniProt Protein Name    Acetyl-CoA carboxylase 1
 UniProt Synonym Protein Names   
ACC-alphaIncluding the following 1 domains:Biotin carboxylase (EC:6.3.4.14
 UniProt Gene Name    ACACA [Similar Products]
 UniProt Synonym Gene Names    ACAC; ACC1; ACCA; ACC1 [Similar Products]
 UniProt Entry Name    ACACA_HUMAN
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 NCBI Summary for ACACA    Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACACA    ACC1: a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland. ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity.

Protein type: EC 6.4.1.2; EC 6.3.4.14; Lipid Metabolism - fatty acid biosynthesis; Carbohydrate Metabolism - pyruvate; Ligase; Carbohydrate Metabolism - propanoate

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: actin cytoskeleton; cytoplasm; cytosol; mitochondrion; nucleolus

Molecular Function: acetyl-CoA carboxylase activity; ATP binding; biotin carboxylase activity; metal ion binding; protein binding

Biological Process: acetyl-CoA metabolic process; biotin metabolic process; carnitine shuttle; cellular lipid metabolic process; energy reserve metabolic process; fatty acid biosynthetic process; lipid homeostasis; multicellular organismal protein metabolic process; positive regulation of cellular metabolic process; protein homotetramerization; tissue homeostasis; triacylglycerol biosynthetic process; vitamin metabolic process; water-soluble vitamin metabolic process

Disease: Acetyl-coa Carboxylase Deficiency
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 Research Articles on ACACA    1. Phospho-acetyl-CoA carboxylase protein expression correlates with tumor grade and the disease stage in gastric cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ACACA blocking peptideDiseases associated with ACACA blocking peptide
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies  Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
 Biotin Transport And Metabolism Pathway antibodies  Biotin Transport And Metabolism Pathway Diagram
 ChREBP Activates Metabolic Gene Expression Pathway antibodies  ChREBP Activates Metabolic Gene Expression Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Defective HLCS Causes Multiple Carboxylase Deficiency Pathway antibodies  Defective HLCS Causes Multiple Carboxylase Deficiency Pathway Diagram
 Defects In Biotin (Btn) Metabolism Pathway antibodies  Defects In Biotin (Btn) Metabolism Pathway Diagram
 Defects In Vitamin And Cofactor Metabolism Pathway antibodies  Defects In Vitamin And Cofactor Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >45 publications with ACACA and Fatty Liver
 Liver Diseases Antibodies  >18 publications with ACACA and Liver Diseases
 Insulin Resistance Antibodies  >17 publications with ACACA and Insulin Resistance
 Inflammation Antibodies  >16 publications with ACACA and Inflammation
 Non-alcoholic Fatty Liver Disease Antibodies  >8 publications with ACACA and Non-alcoholic Fatty Liver Disease
 Weight Gain Antibodies  >7 publications with ACACA and Weight Gain
 Necrosis Antibodies  >5 publications with ACACA and Necrosis
 Hypertriglyceridemia Antibodies  >5 publications with ACACA and Hypertriglyceridemia
 Weight Loss Antibodies  >4 publications with ACACA and Weight Loss
 Diabetes Mellitus Antibodies  >4 publications with ACACA and Diabetes Mellitus
Organs/Tissues associated with ACACA blocking peptide
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >53 publications with ACACA and Liver
 Adipose Tissue Antibodies  >51 publications with ACACA and Adipose Tissue
 Connective Tissue Antibodies  >33 publications with ACACA and Connective Tissue
 Muscle Antibodies  >30 publications with ACACA and Muscle
 Blood Antibodies  >29 publications with ACACA and Blood
 Mammary Gland Antibodies  >23 publications with ACACA and Mammary Gland
 Brain Antibodies  >7 publications with ACACA and Brain
 Vascular Antibodies  >5 publications with ACACA and Vascular
 Ovary Antibodies  >5 publications with ACACA and Ovary
 Heart Antibodies  >5 publications with ACACA and Heart
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