Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Blocking Peptide rightarrow ACE  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • IgG (H&L) (FCGR1A) Secondary Antibody
 • Interferon-induced protein with tetratricopeptide repeats 3,... ELISA Kit
 • Interleukin 24 (IL24) Antibody
 • Phospho Tau Protein (PHOSPHO-TAU) ELISA Kit
 • ADCY2 Antibody
 • Complement Factor P (CFP) ELISA Kit
 • 15 kDa selenoprotein (41532) (SEP15) Recombinant Protein
 • serine dehydratase (SDS) ELISA Kit
 • (R)-2- (2,4-dichlorophenoxy)propio nate,2-oxoglutarate dioxyg... Recombinant Protein
 • Salmonella IgG ELISA Kit
 • Lymphocyte Activation Gene 3 (LAG3) Recombinant Protein
 • PKCD Antibody
 • 16-A-Hydroxyestrogen 1 (16-A-OHE-1) ELISA Kit
 • SAA Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

ACE blocking peptide

Scan QR to view Datasheet Catalog #    MBS9227258 ACE blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACE, Blocking Peptide

 Also Known As   

ACE Antibody (C-term) Blocking Peptide

 Product Synonym Names    Angiotensin-converting enzyme; ACE; 321-; Dipeptidyl carboxypeptidase I; Kininase II; CD143; Angiotensin-converting enzyme; soluble form; ACE; DCP; DCP1
 Product Gene Name   

ACE blocking peptide

[Similar Products]
 Product Synonym Gene Name    DCP; DCP1 [Similar Products]
 Antibody/Peptide Pairs    ACE peptide (MBS9227258) is used for blocking the activity of ACE antibody (MBS9204206)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    106180
 3D Structure    ModBase 3D Structure for P12821
Section Bar
Section Bar
 Specificity    The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human ACE. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
 Form/Format    Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Section Bar
 Cellular Location    Angiotensin-converting enzyme, soluble form: Secreted
 Tissue Location    Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis
Section Bar
 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of ACE blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for ACE blocking peptide

   Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
NCBI/Uniprot data below describe general gene information for ACE. It may not necessarily be applicable to this product.
 NCBI GI #    113045
 NCBI GeneID    1636
 NCBI Accession #    P12821.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P12821 [Other Products]
 UniProt Secondary Accession #    P22966; Q53YX9; Q59GY8; Q7M4L4; B0LPF0; B4DXI3; E7EU16 [Other Products]
 UniProt Related Accession #    P12821 [Other Products]
 Molecular Weight    78,694 Da
Table BarTOPTable Bar
 NCBI Official Full Name    Angiotensin-converting enzyme
 NCBI Official Synonym Full Names    angiotensin I converting enzyme
 NCBI Official Symbol    ACE [Similar Products]
 NCBI Official Synonym Symbols   
DCP; ICH; ACE1; DCP1; CD143; MVCD3
[Similar Products]
 NCBI Protein Information    angiotensin-converting enzyme
 UniProt Protein Name    Angiotensin-converting enzyme
 UniProt Synonym Protein Names   
Dipeptidyl carboxypeptidase I; Kininase II; CD_antigen: CD143
 Protein Family    Acetamidase
 UniProt Gene Name    ACE [Similar Products]
 UniProt Synonym Gene Names    DCP; DCP1; ACE [Similar Products]
 UniProt Entry Name    ACE_HUMAN
Section Bar
 NCBI Summary for ACE    This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]
Section Bar
 UniProt Comments for ACE    ACE: Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. Genetic variations in ACE may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Defects in ACE are a cause of renal tubular dysgenesis (RTD). RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Genetic variations in ACE are associated with susceptibility to microvascular complications of diabetes type 3 (MVCD3). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Defects in ACE are a cause of susceptibility to intracerebral hemorrhage (ICH). A pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke. Belongs to the peptidase M2 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.15.1; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: endosome; external side of plasma membrane; extracellular region; extracellular space; lysosome; plasma membrane

Molecular Function: bradykinin receptor binding; chloride ion binding; drug binding; endopeptidase activity; exopeptidase activity; metallopeptidase activity; mitogen-activated protein kinase binding; mitogen-activated protein kinase kinase binding; peptidyl-dipeptidase activity; tripeptidyl-peptidase activity; zinc ion binding

Biological Process: angiotensin catabolic process in blood; angiotensin maturation; angiotensin mediated regulation of renal output; antigen processing and presentation of peptide antigen via MHC class I; arachidonic acid secretion; beta-amyloid metabolic process; blood vessel remodeling; heart contraction; hormone catabolic process; kidney development; mononuclear cell proliferation; neutrophil mediated immunity; peptide catabolic process; regulation of angiotensin metabolic process; regulation of blood pressure; regulation of smooth muscle cell migration; regulation of systemic arterial blood pressure by renin-angiotensin; regulation of vasoconstriction; regulation of vasodilation; spermatogenesis

Disease: Alzheimer Disease; Hemorrhage, Intracerebral, Susceptibility To; Microvascular Complications Of Diabetes, Susceptibility To, 3; Renal Tubular Dysgenesis
Table BarTOPTable Bar
 Research Articles on ACE    1. a significant association between higher ACE (Angiotensin converting enzyme)activity and the levels of cytokines, namely IL-17a and IFN-gamma (interferon), in patients with SCZ (schizophrenia).
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with ACE blocking peptidePathways associated with ACE blocking peptide
 Reference Product  PubMed Publications
 ACE2 blocking peptide  >623 publications with ACE and ACE2
 AGT blocking peptide  >519 publications with ACE and AGT
 NOS3 blocking peptide  >181 publications with ACE and NOS3
 REN blocking peptide  >181 publications with ACE and REN
 BDKRB2 blocking peptide  >16 publications with ACE and BDKRB2
 ATP6AP2 blocking peptide  >13 publications with ACE and ATP6AP2
 TFPI blocking peptide  >11 publications with ACE and TFPI
 MDK blocking peptide  >3 publications with ACE and MDK
 KNG1 blocking peptide  >2 publications with ACE and KNG1
 SOD3 blocking peptide  >1 publications with ACE and SOD3
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies  Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Renin Secretion Pathway antibodies  Renin Secretion Pathway Diagram
 Renin Secretion Pathway antibodies  Renin Secretion Pathway Diagram
Diseases associated with ACE blocking peptideOrgans/Tissues associated with ACE blocking peptide
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >14427 publications with ACE and Cardiovascular Diseases
 Hypertension Antibodies  >9353 publications with ACE and Hypertension
 Heart Failure Antibodies  >4834 publications with ACE and Heart Failure
 Kidney Diseases Antibodies  >3665 publications with ACE and Kidney Diseases
 Myocardial Infarction Antibodies  >2664 publications with ACE and Myocardial Infarction
 Coronary Disease Antibodies  >2292 publications with ACE and Coronary Disease
 Stroke Antibodies  >1517 publications with ACE and Stroke
 Renal Insufficiency Antibodies  >1417 publications with ACE and Renal Insufficiency
 Respiratory Tract Diseases Antibodies  >1379 publications with ACE and Respiratory Tract Diseases
 Coronary Artery Disease Antibodies  >1304 publications with ACE and Coronary Artery Disease
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >12856 publications with ACE and Blood
 Heart Antibodies  >8705 publications with ACE and Heart
 Vascular Antibodies  >4802 publications with ACE and Vascular
 Kidney Antibodies  >4487 publications with ACE and Kidney
 Muscle Antibodies  >2253 publications with ACE and Muscle
 Lung Antibodies  >1668 publications with ACE and Lung
 Brain Antibodies  >1440 publications with ACE and Brain
 Intestine Antibodies  >301 publications with ACE and Intestine
 Eye Antibodies  >258 publications with ACE and Eye
 Testis Antibodies  >231 publications with ACE and Testis
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions