NP_001456
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
91,651 Da
NCBI Official Full Name
FYN-binding protein isoform 1
NCBI Official Synonym Full Names
FYN binding protein
NCBI Official Synonym Symbols
ADAP; PRO0823; SLAP130; SLAP-130 [Similar Products]
NCBI Protein Information
FYN-binding protein; p120/p130; FYB-120/130; FYN-T-binding protein; SLP-76-associated phosphoprotein; adhesion and degranulation-promoting adaptor protein
UniProt Protein Name
FYN-binding protein
UniProt Synonym Protein Names
Adhesion and degranulation promoting adaptor protein; ADAP; FYB-120/130; p120/p130; FYN-T-binding protein; SLAP-130; SLP-76-associated phosphoprotein
UniProt Synonym Gene Names
UniProt Entry Name
FYB_HUMAN
NCBI Summary for FYB
The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
UniProt Comments for FYB
SLAP-130: an adapter protein for fyn and the SH2-domain-containing leucocyte protein-76 (SLP76) in T cells. T-cell receptor ligation leads to increased tyrosine phosphorylation of SLAP-130. Two alternatively spliced isoforms have been described.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 5p13.1
Cellular Component: nucleus; cytosol; actin cytoskeleton
Molecular Function: protein binding; protein complex binding; receptor binding
Biological Process: immune response; NLS-bearing substrate import into nucleus; signal transduction; T cell receptor signaling pathway; protein amino acid phosphorylation
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Products associated with FYB blocking peptide
Pathways associated with FYB blocking peptide
Diseases associated with FYB blocking peptide
Organs/Tissues associated with FYB blocking peptide
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