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AKT1 blocking peptide :: AKT Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS822967 AKT1 blocking peptide
Unit / Price
1 mg  /  $160 +1 FREE 8GB USB
5 mg  /  $305 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AKT (AKT1), Blocking Peptide

 Also Known As   

AKT Blocking Peptide

 Product Synonym Names    PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha
 Product Gene Name   

AKT1 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    AKT peptide (MBS822967) is used for blocking the activity of AKT antibody (MBS820839)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 615109
 3D Structure    ModBase 3D Structure for P31749
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 Host    Synthetic
 Species Reactivity    Human, Mouse, Rat, Bovine, Pig, Sheep
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 Purity/Purification    >85%
 Form/Format    Lyophilized powder
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 Quality Control    The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Other Notes    Small volumes of AKT1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for AKT1 blocking peptide

   The peptide is used to block Anti-AKT Antibody reactivity.
 Applications Tested/Suitable for AKT1 blocking peptide   

Blocking (BL)

 Application Notes for AKT1 blocking peptide    Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
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NCBI/Uniprot data below describe general gene information for AKT1. It may not necessarily be applicable to this product.
 NCBI GI #    62241013
 NCBI GeneID    207
 NCBI Accession #    NP_001014431.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001014431.1 [Other Products]
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 UniProt Primary Accession #    P31749 [Other Products]
 UniProt Secondary Accession #    Q9BWB6; B2RAM5; B7Z5R1 [Other Products]
 UniProt Related Accession #    P31749 [Other Products]
 Molecular Weight    48,347 Da
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 NCBI Official Full Name    RAC-alpha serine/threonine-protein kinase
 NCBI Official Synonym Full Names    v-akt murine thymoma viral oncogene homolog 1
 NCBI Official Symbol    AKT1 [Similar Products]
 NCBI Official Synonym Symbols   
AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA
[Similar Products]
 NCBI Protein Information    RAC-alpha serine/threonine-protein kinase; AKT1m; PKB alpha; RAC-PK-alpha; proto-oncogene c-Akt; protein kinase B alpha; rac protein kinase alpha
 UniProt Protein Name    RAC-alpha serine/threonine-protein kinase
 UniProt Synonym Protein Names   
Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha
 Protein Family    AKT-interacting protein
 UniProt Gene Name    AKT1 [Similar Products]
 UniProt Synonym Gene Names    PKB; RAC; PKB; PKB alpha [Similar Products]
 UniProt Entry Name    AKT1_HUMAN
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 NCBI Summary for AKT1    The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
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 UniProt Comments for AKT1    Akt1: an oncogenic AGC kinase that plays a critical role in regulating cell survival and metabolism in many different signaling pathways. Dual phosphorylation is required for its activation. T308 is phosphorylated by PDK1 in the PI3 kinase pathway, and S473 is phosphorylated by mTOR in the mTORC2 pathway. The 'Lys-63'-linked ubiquitination of AKT1 by TRAF6 is important for its translocation to the plasma membrane, phosphorylation, and activation. When Akt is fully phosphorylated it translocates into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its proteosomal degradation. Hyperactive or overexpressed in a number of cancers including breast, prostate, lung, pancreatic, liver, ovarian and colorectal. Over 160 protein substrates are known including many that regulate transcription, metabolism, apoptosis, cell cycle, and growth.

Protein type: Protein kinase, AGC; Oncoprotein; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); AGC group; AKT family

Chromosomal Location of Human Ortholog: 14q32.32

Cellular Component: microtubule cytoskeleton; nucleoplasm; mitochondrion; cytoplasm; plasma membrane; spindle; intercellular junction; cytosol; nucleus

Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein binding; enzyme binding; phosphatidylinositol-3,4,5-triphosphate binding; protein kinase C binding; nitric-oxide synthase regulator activity; protein serine/threonine/tyrosine kinase activity; kinase activity; phosphatidylinositol-3,4-bisphosphate binding; ATP binding; protein kinase activity

Biological Process: negative regulation of JNK cascade; regulation of myelination; positive regulation of nitric oxide biosynthetic process; nerve growth factor receptor signaling pathway; protein ubiquitination; glucose homeostasis; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; protein amino acid phosphorylation; regulation of cell migration; germ cell development; positive regulation of glucose import; cell projection organization and biogenesis; protein catabolic process; maternal placenta development; response to food; platelet activation; glycogen biosynthetic process; fibroblast growth factor receptor signaling pathway; positive regulation of nitric-oxide synthase activity; positive regulation of blood vessel endothelial cell migration; glucose metabolic process; positive regulation of lipid biosynthetic process; positive regulation of cell growth; cellular response to insulin stimulus; insulin-like growth factor receptor signaling pathway; response to heat; T cell costimulation; positive regulation of fat cell differentiation; striated muscle cell differentiation; negative regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; positive regulation of transcription factor activity; regulation of nitric-oxide synthase activity; response to oxidative stress; negative regulation of apoptosis; negative regulation of autophagy; negative regulation of fatty acid beta-oxidation; translation; apoptosis; protein amino acid autophosphorylation; positive regulation of cellular protein metabolic process; regulation of glycogen biosynthetic process; positive regulation of glycogen biosynthetic process; negative regulation of cell size; glucose transport; negative regulation of caspase activity; signal transduction; nitric oxide metabolic process; regulation of translation; apoptotic mitochondrial changes; protein kinase B signaling cascade; inflammatory response; nitric oxide biosynthetic process; cell differentiation; activated T cell apoptosis; aging; negative regulation of proteolysis; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; myelin maintenance in the peripheral nervous system; protein modification process; positive regulation of peptidyl-serine phosphorylation; endocrine pancreas development; osteoblast differentiation; G-protein coupled receptor protein signaling pathway; cell proliferation; peptidyl-serine phosphorylation; protein import into nucleus, translocation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of vasoconstriction; insulin receptor signaling pathway; innate immune response; gene expression; positive regulation of protein amino acid phosphorylation; blood coagulation; vascular endothelial growth factor receptor signaling pathway; phosphorylation; hyaluronan metabolic process

Disease: Schizophrenia; Cowden Syndrome 6; Proteus Syndrome; Breast Cancer; Ovarian Cancer
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 Research Articles on AKT1    1. Data suggest that the ribosomal S6 kinase : protein kinase B (AKT) phosphorylation ratio could be useful as a biomarker of target inhibition by RAD001.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AKT1 blocking peptidePathways associated with AKT1 blocking peptide
 Reference Product  PubMed Publications
 PTEN blocking peptide  >508 publications with AKT1 and PTEN
 MTOR blocking peptide  >425 publications with AKT1 and MTOR
 FOXO1 blocking peptide  >130 publications with AKT1 and FOXO1
 MDM2 blocking peptide  >50 publications with AKT1 and MDM2
 TSC2 blocking peptide  >39 publications with AKT1 and TSC2
 PIK3CB blocking peptide  >18 publications with AKT1 and PIK3CB
 TERT blocking peptide  >14 publications with AKT1 and TERT
 GSK3B blocking peptide  >9 publications with AKT1 and GSK3B
 UBC blocking peptide  >6 publications with AKT1 and UBC
 HSP90AA1 blocking peptide  >3 publications with AKT1 and HSP90AA1
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 AKT Phosphorylates Targets In The Cytosol Pathway antibodies  AKT Phosphorylates Targets In The Cytosol Pathway Diagram
 AKT Phosphorylates Targets In The Nucleus Pathway antibodies  AKT Phosphorylates Targets In The Nucleus Pathway Diagram
 AKT-mediated Inactivation Of FOXO1A Pathway antibodies  AKT-mediated Inactivation Of FOXO1A Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
Diseases associated with AKT1 blocking peptideOrgans/Tissues associated with AKT1 blocking peptide
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >397 publications with AKT1 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >344 publications with AKT1 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >299 publications with AKT1 and Nervous System Diseases
 Necrosis Antibodies  >295 publications with AKT1 and Necrosis
 Lung Neoplasms Antibodies  >229 publications with AKT1 and Lung Neoplasms
 Prostatic Neoplasms Antibodies  >193 publications with AKT1 and Prostatic Neoplasms
 Neoplasms, Experimental Antibodies  >192 publications with AKT1 and Neoplasms, Experimental
 Inflammation Antibodies  >175 publications with AKT1 and Inflammation
 Heart Diseases Antibodies  >149 publications with AKT1 and Heart Diseases
 Colorectal Neoplasms Antibodies  >135 publications with AKT1 and Colorectal Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >779 publications with AKT1 and Blood
 Muscle Antibodies  >679 publications with AKT1 and Muscle
 Vascular Antibodies  >669 publications with AKT1 and Vascular
 Brain Antibodies  >476 publications with AKT1 and Brain
 Lung Antibodies  >359 publications with AKT1 and Lung
 Heart Antibodies  >302 publications with AKT1 and Heart
 Liver Antibodies  >291 publications with AKT1 and Liver
 Nerve Antibodies  >244 publications with AKT1 and Nerve
 Prostate Antibodies  >240 publications with AKT1 and Prostate
 Kidney Antibodies  >171 publications with AKT1 and Kidney
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