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AKT1S1 blocking peptide

Scan QR to view Datasheet Catalog #    MBS153935 AKT1S1 blocking peptide
Unit / Price
0.05 mg  /  $135 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AKT1S1, Blocking Peptide

 Also Known As   

AKT1S1 Peptide

 Product Synonym Names    Lobe; PRAS40; Proline-rich AKT1 substrate 1; 40 kDa proline-rich AKT substrate; AKT1 substrate 1 (proline-rich)
 Product Gene Name   

AKT1S1 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    AKT1S1 peptide (MBS153935) is used for blocking the activity of AKT1S1 antibody (MBS153593)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Western Blot Protocol    Western Blot Peptide Blocking Protocol
 OMIM    610221
 3D Structure    ModBase 3D Structure for Q96B36
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 Form/Format    Liquid
 Concentration    200 ug/mL (lot specific)
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 Species    Human
 Buffer    PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
 Location    19 amino acids near the carboxy terminus of human AKT1S1.
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 Preparation and Storage    Store AKT1S1 peptide at -20 degree C, stable for one year.
 Other Notes    Small volumes of AKT1S1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for AKT1S1 blocking peptide   

Blocking (BL)

 Application Notes for AKT1S1 blocking peptide    The peptide is used for blocking the activity of AKT1S1 antibody. It usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37 degree C.
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NCBI/Uniprot data below describe general gene information for AKT1S1. It may not necessarily be applicable to this product.
 NCBI GI #    400153980
 NCBI GeneID    84335
 NCBI Accession #    NP_115751 [Other Products]
 NCBI GenBank Nucleotide #    NM_032375.5 [Other Products]
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 UniProt Primary Accession #    Q96B36 [Other Products]
 UniProt Secondary Accession #    Q96BI4; Q96IK7; Q96NG2; Q9BWR5; A8MTQ1; B2RE93; J3KPM3 [Other Products]
 UniProt Related Accession #    Q96B36 [Other Products]
 Molecular Weight    29,262 Da
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 NCBI Official Full Name    proline-rich AKT1 substrate 1 isoform a
 NCBI Official Synonym Full Names    AKT1 substrate 1 (proline-rich)
 NCBI Official Symbol    AKT1S1 [Similar Products]
 NCBI Official Synonym Symbols   
Lobe; PRAS40
[Similar Products]
 NCBI Protein Information    proline-rich AKT1 substrate 1; AKT1S1; 40 kDa proline-rich AKT substrate
 UniProt Protein Name    Proline-rich AKT1 substrate 1
 UniProt Synonym Protein Names   
40 kDa proline-rich AKT substrate
 Protein Family    Proline-rich AKT1 substrate
 UniProt Gene Name    AKT1S1 [Similar Products]
 UniProt Entry Name    AKTS1_HUMAN
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 NCBI Summary for AKT1S1    AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for AKT1S1    Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. Inhibits RHEB-GTP-dependent mTORC1 activation. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. May also play a role in nerve growth factor-mediated neuroprotection.
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 Research Articles on AKT1S1    1. PRAS40 as a regulator of insulin sensitivity in hSkMC
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AKT1S1 blocking peptidePathways associated with AKT1S1 blocking peptide
 Reference Product  PubMed Publications
 MTOR blocking peptide  >30 publications with AKT1S1 and MTOR
 RPTOR blocking peptide  >8 publications with AKT1S1 and RPTOR
 RHEB blocking peptide  >6 publications with AKT1S1 and RHEB
 MLST8 blocking peptide  >3 publications with AKT1S1 and MLST8
 AKT1 blocking peptide  >3 publications with AKT1S1 and AKT1
 AKT2 blocking peptide  >2 publications with AKT1S1 and AKT2
 Products by Pathway  Pathway Diagram
 AKT Phosphorylates Targets In The Cytosol Pathway antibodies  AKT Phosphorylates Targets In The Cytosol Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cellular Response To Heat Stress Pathway antibodies  Cellular Response To Heat Stress Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
Diseases associated with AKT1S1 blocking peptideOrgans/Tissues associated with AKT1S1 blocking peptide
 Disease Name  Pubmed Publications
 Metabolic Diseases Antibodies  >10 publications with AKT1S1 and Metabolic Diseases
 Hypertrophy Antibodies  >4 publications with AKT1S1 and Hypertrophy
 Kidney Diseases Antibodies  >3 publications with AKT1S1 and Kidney Diseases
 Fibrosis Antibodies  >1 publications with AKT1S1 and Fibrosis
 Infertility, Female Antibodies  >1 publications with AKT1S1 and Infertility, Female
 Adenocarcinoma Antibodies  >1 publications with AKT1S1 and Adenocarcinoma
 Fatty Liver Antibodies  >1 publications with AKT1S1 and Fatty Liver
 Necrosis Antibodies  >1 publications with AKT1S1 and Necrosis
 Spinal Cord Injuries Antibodies  >1 publications with AKT1S1 and Spinal Cord Injuries
 Reperfusion Injury Antibodies  >1 publications with AKT1S1 and Reperfusion Injury
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with AKT1S1 and Blood
 Kidney Antibodies  >6 publications with AKT1S1 and Kidney
 Heart Antibodies  >6 publications with AKT1S1 and Heart
 Lung Antibodies  >5 publications with AKT1S1 and Lung
 Prostate Antibodies  >5 publications with AKT1S1 and Prostate
 Muscle Antibodies  >5 publications with AKT1S1 and Muscle
 Liver Antibodies  >3 publications with AKT1S1 and Liver
 Brain Antibodies  >3 publications with AKT1S1 and Brain
 Eye Antibodies  >2 publications with AKT1S1 and Eye
 Vascular Antibodies  >2 publications with AKT1S1 and Vascular
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