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AKT2 blocking peptide

Scan QR to view Datasheet Catalog #    MBS823943 AKT2 blocking peptide
Unit / Price
1 mg  /  $160 +1 FREE 8GB USB
5 mg  /  $305 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AKT2, Blocking Peptide

 Also Known As   

AKT2 Blocking Peptide

 Product Synonym Names    RAC-beta serine/threonine-protein kinase; Protein kinase Akt-2; Protein kinase B beta; PKB beta; RAC-PK-beta
 Product Gene Name   

AKT2 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    AKT2 peptide (MBS823943) is used for blocking the activity of AKT2 antibody (MBS820210)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 240900
 3D Structure    ModBase 3D Structure for P31751
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 Host    Synthetic
 Species Reactivity    Human, Mouse, Rat, Chicken, Dog
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 Purity/Purification    >85%
 Form/Format    Lyophilized powder
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 Quality Control    The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Other Notes    Small volumes of AKT2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for AKT2 blocking peptide

   The peptide is used to block Anti-AKT2 Antibody reactivity.
 Applications Tested/Suitable for AKT2 blocking peptide   

Blocking (BL)

 Application Notes for AKT2 blocking peptide    Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
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NCBI/Uniprot data below describe general gene information for AKT2. It may not necessarily be applicable to this product.
 NCBI GI #    4502023
 NCBI GeneID    208
 NCBI Accession #    NP_001617.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001626.5 [Other Products]
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 UniProt Primary Accession #    P31751 [Other Products]
 UniProt Secondary Accession #    Q05BV0; Q0VAN0; Q0VAN1; Q68GC0; B2RBD8 [Other Products]
 UniProt Related Accession #    P31751 [Other Products]
 Molecular Weight    51,083 Da
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 NCBI Official Full Name    RAC-beta serine/threonine-protein kinase isoform 1
 NCBI Official Synonym Full Names    v-akt murine thymoma viral oncogene homolog 2
 NCBI Official Symbol    AKT2 [Similar Products]
 NCBI Official Synonym Symbols   
PKBB; PRKBB; HIHGHH; PKBBETA; RAC-BETA
[Similar Products]
 NCBI Protein Information    RAC-beta serine/threonine-protein kinase; PKB beta; RAC-PK-beta; protein kinase Akt-2; protein kinase B beta; rac protein kinase beta; murine thymoma viral (v-akt) homolog-2
 UniProt Protein Name    RAC-beta serine/threonine-protein kinase
 UniProt Synonym Protein Names   
Protein kinase Akt-2; Protein kinase B beta; PKB beta; RAC-PK-beta
 Protein Family    Potassium channel
 UniProt Gene Name    AKT2 [Similar Products]
 UniProt Synonym Gene Names    PKB beta [Similar Products]
 UniProt Entry Name    AKT2_HUMAN
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 NCBI Summary for AKT2    This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AKT2    Akt2: an AGC kinase. Plays critical roles in glucose metabolism and the development or maintenance of proper adipose tissue and islet mass for which other Akt/PKB isoforms are unable to fully compensate. Amplified and overexpressed in human ovarian carcinoma cell lines and amplified in some primary ovarian and pancreatic tumors. Antisense blocks invasiveness in xenografts. Expressed in several insulin-responsive tissues, and one case of Type II diabetes has been associated with a likely LOF point mutation. Mouse mutants have defects in insulin response.

Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; Oncoprotein; Kinase, protein; AGC group; AKT family

Chromosomal Location of Human Ortholog: 19q13.1-q13.2

Cellular Component: nucleoplasm; plasma membrane; cell cortex; cytosol; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; kinase activity; ATP binding

Biological Process: fat cell differentiation; glycogen biosynthetic process; apoptosis; positive regulation of glycogen biosynthetic process; carbohydrate transport; myelin maintenance in the peripheral nervous system; intracellular protein transport across a membrane; positive regulation of vesicle fusion; glucose metabolic process; protein modification process; signal transduction; regulation of cell migration; protein amino acid phosphorylation; positive regulation of fatty acid beta-oxidation; regulation of translation; positive regulation of glucose import; cellular response to insulin stimulus; insulin receptor signaling pathway; positive regulation of protein amino acid phosphorylation

Disease: Hypoinsulinemic Hypoglycemia With Hemihypertrophy; Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on AKT2    1. Results show that miR-302b inhibits hepatocellular carcinoma cell proliferation and growth in vitro and in vivo by targeting AKT2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AKT2 blocking peptidePathways associated with AKT2 blocking peptide
 Reference Product  PubMed Publications
 MTOR blocking peptide  >91 publications with AKT2 and MTOR
 FOXO1 blocking peptide  >28 publications with AKT2 and FOXO1
 TSC2 blocking peptide  >7 publications with AKT2 and TSC2
 INS blocking peptide  >3 publications with AKT2 and INS
 GSK3B blocking peptide  >2 publications with AKT2 and GSK3B
 AKT1S1 blocking peptide  >2 publications with AKT2 and AKT1S1
 CHUK blocking peptide  >1 publications with AKT2 and CHUK
 TCL1A blocking peptide  >1 publications with AKT2 and TCL1A
 Products by Pathway  Pathway Diagram
 AKT Phosphorylates Targets In The Cytosol Pathway antibodies  AKT Phosphorylates Targets In The Cytosol Pathway Diagram
 AKT Phosphorylates Targets In The Nucleus Pathway antibodies  AKT Phosphorylates Targets In The Nucleus Pathway Diagram
 AKT-mediated Inactivation Of FOXO1A Pathway antibodies  AKT-mediated Inactivation Of FOXO1A Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Activation Of PKB Pathway antibodies  Activation Of PKB Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
Diseases associated with AKT2 blocking peptideOrgans/Tissues associated with AKT2 blocking peptide
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >78 publications with AKT2 and Breast Neoplasms
 Adenocarcinoma Antibodies  >69 publications with AKT2 and Adenocarcinoma
 Ovarian Neoplasms Antibodies  >66 publications with AKT2 and Ovarian Neoplasms
 Liver Diseases Antibodies  >39 publications with AKT2 and Liver Diseases
 Neoplasms, Experimental Antibodies  >34 publications with AKT2 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >33 publications with AKT2 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >31 publications with AKT2 and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >29 publications with AKT2 and Liver Neoplasms
 Brain Diseases Antibodies  >26 publications with AKT2 and Brain Diseases
 Hyperglycemia Antibodies  >25 publications with AKT2 and Hyperglycemia
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >184 publications with AKT2 and Muscle
 Blood Antibodies  >125 publications with AKT2 and Blood
 Liver Antibodies  >95 publications with AKT2 and Liver
 Lung Antibodies  >66 publications with AKT2 and Lung
 Vascular Antibodies  >57 publications with AKT2 and Vascular
 Heart Antibodies  >46 publications with AKT2 and Heart
 Adipose Tissue Antibodies  >43 publications with AKT2 and Adipose Tissue
 Brain Antibodies  >43 publications with AKT2 and Brain
 Bone Antibodies  >36 publications with AKT2 and Bone
 Connective Tissue Antibodies  >29 publications with AKT2 and Connective Tissue
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