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ANO1 blocking peptide

Scan QR to view Datasheet Catalog #    MBS8208820 ANO1 blocking peptide
Unit / Price
1 mg  /  $160 +1 FREE 8GB USB
5 mg  /  $305 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ANO1, Blocking Peptide

 Also Known As   

ANO1 Blocking Peptide

 Product Synonym Names    DOG1; ORAOV2; TAOS2; TMEM16A; Anoctamin-1; Discovered on gastrointestinal stromal tumors protein 1; Oral cancer overexpressed protein 2; Transmembrane protein 16A; Tumor-amplified and overexpressed sequence 2
 Product Gene Name   

ANO1 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    ANO1 peptide (MBS8208820) is used for blocking the activity of ANO1 antibody (MBS8211629)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    610108
 3D Structure    ModBase 3D Structure for Q5XXA6
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 Host    Synthetic
 Species Reactivity    Human, Rat, Monkey
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 Purity/Purification    >85%
 Form/Format    Lyophilized powder
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 Quality Control    The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
 Directions for Use    Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Other Notes    Small volumes of ANO1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for ANO1 blocking peptide

   The peptide is used to block Anti-ANO1 Antibody reactivity.
 Applications Tested/Suitable for ANO1 blocking peptide   

Blocking (BL)

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NCBI/Uniprot data below describe general gene information for ANO1. It may not necessarily be applicable to this product.
 NCBI GI #    194306539
 NCBI GeneID    55107
 NCBI Accession #    NP_060513.5 [Other Products]
 NCBI GenBank Nucleotide #    NM_018043.5 [Other Products]
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 UniProt Primary Accession #    Q5XXA6 [Other Products]
 UniProt Secondary Accession #    Q8IYY8; Q8N7V3; A8KAM3 [Other Products]
 UniProt Related Accession #    Q5XXA6 [Other Products]
 Molecular Weight    74,369 Da
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 NCBI Official Full Name    anoctamin-1
 NCBI Official Synonym Full Names    anoctamin 1, calcium activated chloride channel
 NCBI Official Symbol    ANO1 [Similar Products]
 NCBI Official Synonym Symbols   
DOG1; TAOS2; ORAOV2; TMEM16A
[Similar Products]
 NCBI Protein Information    anoctamin-1
 UniProt Protein Name    Anoctamin-1
 UniProt Synonym Protein Names   
Discovered on gastrointestinal stromal tumors protein 1; Oral cancer overexpressed protein 2; Transmembrane protein 16A; Tumor-amplified and overexpressed sequence 2
 Protein Family    Anoctamin
 UniProt Gene Name    ANO1 [Similar Products]
 UniProt Synonym Gene Names    DOG1; ORAOV2; TAOS2; TMEM16A [Similar Products]
 UniProt Entry Name    ANO1_HUMAN
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 UniProt Comments for ANO1    ANO1: Acts as a calcium-activated chloride channel. Required for normal tracheal development. Belongs to the anoctamin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ion channel; Transporter; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: apical plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane

Molecular Function: protein binding; protein homodimerization activity; intracellular calcium activated chloride channel activity; protein heterodimerization activity; calcium activated cation channel activity

Biological Process: regulation of membrane potential; multicellular organismal development; chloride transport; transmembrane transport; cation transport
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 Research Articles on ANO1    1. This is the first demonstration that the TMEM16A-NF-kappaB pathway is positively involved in IL-13-induced mucus production, which provides novel insight into the molecular mechanism of mucin overproduction.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ANO1 blocking peptidePathways associated with ANO1 blocking peptide
 Reference Product  PubMed Publications
 CFTR blocking peptide  >28 publications with ANO1 and CFTR
 PDGFRA blocking peptide  >26 publications with ANO1 and PDGFRA
 BEST1 blocking peptide  >5 publications with ANO1 and BEST1
 SLC26A6 blocking peptide  >1 publications with ANO1 and SLC26A6
 Products by Pathway  Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
Diseases associated with ANO1 blocking peptideOrgans/Tissues associated with ANO1 blocking peptide
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >13 publications with ANO1 and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >10 publications with ANO1 and Adenocarcinoma
 Inflammation Antibodies  >8 publications with ANO1 and Inflammation
 Cardiovascular Diseases Antibodies  >7 publications with ANO1 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >7 publications with ANO1 and Breast Neoplasms
 Kidney Diseases Antibodies  >5 publications with ANO1 and Kidney Diseases
 Uterine Neoplasms Antibodies  >5 publications with ANO1 and Uterine Neoplasms
 Neoplasms, Experimental Antibodies  >4 publications with ANO1 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >4 publications with ANO1 and Disease Models, Animal
 Prostatic Neoplasms Antibodies  >3 publications with ANO1 and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >76 publications with ANO1 and Muscle
 Intestine Antibodies  >29 publications with ANO1 and Intestine
 Vascular Antibodies  >21 publications with ANO1 and Vascular
 Stomach Antibodies  >21 publications with ANO1 and Stomach
 Lung Antibodies  >18 publications with ANO1 and Lung
 Brain Antibodies  >14 publications with ANO1 and Brain
 Kidney Antibodies  >14 publications with ANO1 and Kidney
 Salivary Gland Antibodies  >12 publications with ANO1 and Salivary Gland
 Mouth Antibodies  >11 publications with ANO1 and Mouth
 Pancreas Antibodies  >11 publications with ANO1 and Pancreas
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