NP_001174.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,026 Da
NCBI Official Full Name
V-type proton ATPase subunit S1
NCBI Official Synonym Full Names
ATPase, H+ transporting, lysosomal accessory protein 1
NCBI Official Synonym Symbols
16A; CF2; Ac45; XAP3; XAP-3; ATP6S1; VATPS1; ATP6IP1 [Similar Products]
NCBI Protein Information
V-type proton ATPase subunit S1; protein XAP-3; H-ATPase subunit; V-ATPase subunit S1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; vacuolar proton pump subunit S1; ATPase, H+ transporting, lysosomal interacting protein 1; ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1
UniProt Protein Name
V-type proton ATPase subunit S1
UniProt Synonym Protein Names
Protein XAP-3; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; Vacuolar proton pump subunit S1
UniProt Synonym Gene Names
UniProt Entry Name
VAS1_HUMAN
NCBI Summary for ATP6AP1
This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013]
UniProt Comments for ATP6AP1
ATP6AP1: Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the vacuolar ATPase subunit S1 family.
Protein type: Membrane protein, integral; Energy Metabolism - oxidative phosphorylation; Hydrolase; EC 3.6.3.14; Transporter
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: vacuolar membrane; integral to membrane; endosome membrane; proton-transporting two-sector ATPase complex
Molecular Function: transporter activity; hydrogen ion transporting ATP synthase activity, rotational mechanism; hydrogen ion transporting ATPase activity, rotational mechanism; ATP binding; Rab GTPase binding
Biological Process: positive regulation of osteoblast differentiation; proton transport; cellular iron ion homeostasis; pH reduction; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; positive regulation of bone resorption; transmembrane transport; establishment of organelle localization; positive regulation of exocytosis
Research Articles on ATP6AP1
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Products associated with ATP6AP1 blocking peptide
Pathways associated with ATP6AP1 blocking peptide
Diseases associated with ATP6AP1 blocking peptide
Organs/Tissues associated with ATP6AP1 blocking peptide
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