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AAK1 blocking peptide

Scan QR to view Datasheet Catalog #    MBS152453 AAK1 blocking peptide
Unit / Price
0.05 mg  /  $140 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Aak1, Blocking Peptide

 Also Known As   

Aak1 Peptide

 Product Synonym Names    KIAA1048; AP2-associated protein kinase 1; Adaptor-associated kinase 1; AP2 associated kinase 1
 Product Gene Name   

AAK1 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    Aak1 peptide (MBS152453) is used for blocking the activity of Aak1 antibody (MBS150292)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Western Blot Protocol    Western Blot Peptide Blocking Protocol
 3D Structure    ModBase 3D Structure for Q2M2I8
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 Form/Format    Liquid
 Concentration    200 ug/mL (lot specific)
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 Species    Human
 Buffer    PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
 Location    18 amino acids near the carboxy terminus of human Aak1.
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 Preparation and Storage    Store Aak1 peptide at -20 degree C, stable for one year.
 Other Notes    Small volumes of AAK1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for AAK1 blocking peptide   

Blocking (BL)

 Application Notes for AAK1 blocking peptide    Aak1 peptide is used for blocking the activity of Aak1 antibody.
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NCBI/Uniprot data below describe general gene information for AAK1. It may not necessarily be applicable to this product.
 NCBI GI #    148277037
 NCBI GeneID    22848
 NCBI Accession #    NP_055726 [Other Products]
 NCBI GenBank Nucleotide #    NM_014911.3 [Other Products]
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 UniProt Primary Accession #    Q2M2I8 [Other Products]
 UniProt Secondary Accession #    Q4ZFZ3; Q53RX6; Q9UPV4 [Other Products]
 UniProt Related Accession #    Q2M2I8 [Other Products]
 Molecular Weight    93,578 Da
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 NCBI Official Full Name    AP2-associated protein kinase 1
 NCBI Official Synonym Full Names    AP2 associated kinase 1
 NCBI Official Symbol    AAK1 [Similar Products]
 NCBI Protein Information    AP2-associated protein kinase 1; adaptor-associated kinase 1
 UniProt Protein Name    AP2-associated protein kinase 1
 UniProt Synonym Protein Names   
Adaptor-associated kinase 1
 Protein Family    AP2-associated protein kinase
 UniProt Gene Name    AAK1 [Similar Products]
 UniProt Synonym Gene Names    KIAA1048 [Similar Products]
 UniProt Entry Name    AAK1_HUMAN
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 NCBI Summary for AAK1    Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AAK1    AAK1: an NAK kinase. Plays a regulatory role in clathrin-mediated endocytosis, including the regulation of fatty acid synthesis and cholesterol synthesis.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Kinase, protein; EC 2.7.11.1; Other group; NAK family

Chromosomal Location of Human Ortholog: 2p14

Cellular Component: extrinsic to plasma membrane; clathrin-coated vesicle; leading edge; terminal button; coated pit

Molecular Function: protein serine/threonine kinase activity; protein binding; Notch binding; ATP binding

Biological Process: regulation of protein localization; protein stabilization; protein amino acid autophosphorylation; endocytosis; protein amino acid phosphorylation; positive regulation of Notch signaling pathway
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 Research Articles on AAK1    1. AAK1 increases the localization of activated Notch to Rab5-positive endocytic vesicles, while AAK1 depletion or overexpression of Numb, an inhibitor of the pathway, interferes with this localization.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AAK1 blocking peptideDiseases associated with AAK1 blocking peptide
 Reference Product  PubMed Publications
 EPS15 blocking peptide  >3 publications with AAK1 and EPS15
 NUMB blocking peptide  >2 publications with AAK1 and NUMB
 AP2M1 blocking peptide  >1 publications with AAK1 and AP2M1
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with AAK1 and Inflammation
Organs/Tissues associated with AAK1 blocking peptide
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >6 publications with AAK1 and Nerve
 Brain Antibodies  >5 publications with AAK1 and Brain
 Blood Antibodies  >4 publications with AAK1 and Blood
 Kidney Antibodies  >2 publications with AAK1 and Kidney
 Vascular Antibodies  >1 publications with AAK1 and Vascular
 Heart Antibodies  >1 publications with AAK1 and Heart
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