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ACIN1 blocking peptide :: Acinus Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS152484 ACIN1 blocking peptide
Unit / Price
0.05 mg  /  $140 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Acinus (ACIN1), Blocking Peptide

 Also Known As   

Acinus Peptide

 Product Synonym Names    ACN; ACINUS; fSAP152; KIAA0670; Apoptotic chromatin condensation inducer in the nucleus; Acinus; apoptotic chromatin condensation inducer 1
 Product Gene Name   

ACIN1 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    Acinus peptide (MBS152484) is used for blocking the activity of Acinus antibody (MBS151348)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Western Blot Protocol    Western Blot Peptide Blocking Protocol
 OMIM    604562
 3D Structure    ModBase 3D Structure for Q9UKV3
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 Form/Format    Liquid
 Concentration    200 ug/mL (lot specific)
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 Species    Human
 Buffer    PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
 Location    16 amino amino terminus of human Acinus.
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 Preparation and Storage    Store Acinus peptide at -20 degree C, stable for one year.
 Other Notes    Small volumes of ACIN1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for ACIN1 blocking peptide   

Blocking (BL)

 Application Notes for ACIN1 blocking peptide    Acinus peptide is used for blocking the activity of Acinus antibody.
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NCBI/Uniprot data below describe general gene information for ACIN1. It may not necessarily be applicable to this product.
 NCBI GI #    5931959
 NCBI GeneID    22985
 NCBI Accession #    AAD56724 [Other Products]
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 UniProt Primary Accession #    Q9UKV3 [Other Products]
 UniProt Secondary Accession #    O75158; Q9UG91; Q9UKV1; Q9UKV2; B2RTT4; D3DS45 [Other Products]
 UniProt Related Accession #    Q9UKV3 [Other Products]
 Molecular Weight    150,557 Da
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 NCBI Official Full Name    acinusL
 NCBI Official Synonym Full Names    apoptotic chromatin condensation inducer 1
 NCBI Official Symbol    ACIN1 [Similar Products]
 NCBI Official Synonym Symbols   
ACN; ACINUS; fSAP152
[Similar Products]
 NCBI Protein Information    apoptotic chromatin condensation inducer in the nucleus; functional spliceosome-associated protein 152
 UniProt Protein Name    Apoptotic chromatin condensation inducer in the nucleus
 Protein Family    Apoptotic chromatin condensation inducer in the nucleus
 UniProt Gene Name    ACIN1 [Similar Products]
 UniProt Synonym Gene Names    ACINUS; KIAA0670; Acinus [Similar Products]
 UniProt Entry Name    ACINU_HUMAN
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 NCBI Summary for ACIN1    Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
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 UniProt Comments for ACIN1    acinus: an ubiquitous RNA-binding protein. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC is composed of ACIN1, CASC3, DDX48, MAGOH, PNN, RBM8A, RNPS1, SAP18 and THOC4. Forms heterodimers with RNPS1. Found in a heterotrimeric complex with ACIN1, RNPS1 and SAP18. Interacts with API5. Phosphorylation by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm, and up-regulates its stimulatory effect on cyclin A1. Activated by proteolytic cleavage. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. Four alternatively spliced human isoforms have been described.

Protein type: Spliceosome; RNA splicing; RNA-binding; Apoptosis

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: nucleoplasm; cytoplasm; nucleolus; plasma membrane; nuclear speck; cytosol; nucleus

Molecular Function: protein binding; enzyme binding; nucleic acid binding; ATPase activity; nucleotide binding

Biological Process: positive regulation of monocyte differentiation; negative regulation of nuclear mRNA splicing, via spliceosome; apoptosis; positive regulation of apoptosis; RNA splicing; erythrocyte differentiation; mRNA processing; apoptotic chromosome condensation; cell structure disassembly during apoptosis
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 Research Articles on ACIN1    1. An electronegative region on acinusS restricts SRPK2 phosphorylation to a single specific site.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ACIN1 blocking peptidePathways associated with ACIN1 blocking peptide
 Reference Product  PubMed Publications
 CASP3 blocking peptide  >5 publications with ACIN1 and CASP3
 SAP18 blocking peptide  >5 publications with ACIN1 and SAP18
 RNPS1 blocking peptide  >5 publications with ACIN1 and RNPS1
 SRPK2 blocking peptide  >2 publications with ACIN1 and SRPK2
 API5 blocking peptide  >1 publications with ACIN1 and API5
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Exon Junction Complex (EJC) Pathway antibodies  Exon Junction Complex (EJC) Pathway Diagram
 Exon Junction Complex (EJC) Pathway antibodies  Exon Junction Complex (EJC) Pathway Diagram
 Programmed Cell Death Pathway antibodies  Programmed Cell Death Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
Diseases associated with ACIN1 blocking peptideOrgans/Tissues associated with ACIN1 blocking peptide
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >1 publications with ACIN1 and Heart Diseases
 Inflammation Antibodies  >1 publications with ACIN1 and Inflammation
 Hyperplasia Antibodies  >1 publications with ACIN1 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with ACIN1 and Lung
 Blood Antibodies  >2 publications with ACIN1 and Blood
 Heart Antibodies  >1 publications with ACIN1 and Heart
 Thymus Antibodies  >1 publications with ACIN1 and Thymus
 Stomach Antibodies  >1 publications with ACIN1 and Stomach
 Muscle Antibodies  >1 publications with ACIN1 and Muscle
 Prostate Antibodies  >1 publications with ACIN1 and Prostate
 Pancreas Antibodies  >1 publications with ACIN1 and Pancreas
 Liver Antibodies  >1 publications with ACIN1 and Liver
 Bone Antibodies  >1 publications with ACIN1 and Bone
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