P68032.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,019 Da
NCBI Official Full Name
Actin, alpha cardiac muscle 1
NCBI Official Synonym Full Names
actin, alpha, cardiac muscle 1
NCBI Official Synonym Symbols
ACTC; ASD5; CMD1R; CMH11; LVNC4 [Similar Products]
NCBI Protein Information
actin, alpha cardiac muscle 1
UniProt Protein Name
Actin, alpha cardiac muscle 1
UniProt Synonym Protein Names
Alpha-cardiac actin
UniProt Synonym Gene Names
UniProt Entry Name
ACTC_HUMAN
NCBI Summary for ACTC1
Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008]
UniProt Comments for ACTC1
ACTC1: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Belongs to the actin family.
Protein type: Cytoskeletal; Contractile; Cell development/differentiation; Motility/polarity/chemotaxis; Myosin-binding
Chromosomal Location of Human Ortholog: 15q14
Cellular Component: actin filament; cytoplasm; cytosol; extracellular space; filopodium; focal adhesion; I band; lamellipodium; membrane; sarcomere
Molecular Function: ATP binding; ATPase activity; myosin binding
Biological Process: actin filament-based movement; actin-myosin filament sliding; actomyosin structure organization and biogenesis; apoptosis; cardiac muscle morphogensis; cardiac myofibril assembly; heart contraction; muscle filament sliding; muscle thin filament assembly
Disease: Atrial Septal Defect 5; Cardiomyopathy, Dilated, 1r; Cardiomyopathy, Familial Hypertrophic, 11
Research Articles on ACTC1
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Pathways associated with ACTC1 blocking peptide
Diseases associated with ACTC1 blocking peptide
Organs/Tissues associated with ACTC1 blocking peptide
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