Q04771.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
57,153 Da
NCBI Official Full Name
Activin receptor type-1
NCBI Official Synonym Full Names
activin A receptor type 1
NCBI Official Synonym Symbols
FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2 [Similar Products]
NCBI Protein Information
activin receptor type-1
UniProt Protein Name
Activin receptor type-1
UniProt Synonym Protein Names
Activin receptor type I; ACTR-I; Activin receptor-like kinase 2; ALK-2; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I
UniProt Synonym Gene Names
UniProt Entry Name
ACVR1_HUMAN
NCBI Summary for ACVR1
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]
UniProt Comments for ACVR1
ALK2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. Interacts with FKBP1A. Interacts with FCHO1. Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Protein type: Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; EC 2.7.11.30; Membrane protein, integral; Kinase, protein; TKL group; STKR family; Type1 subfamily
Chromosomal Location of Human Ortholog: 2q23-q24
Cellular Component: activin receptor complex; integral to plasma membrane
Molecular Function: activin binding; activin receptor activity, type I; ATP binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; SMAD binding; transforming growth factor beta binding
Biological Process: activin receptor signaling pathway; BMP signaling pathway; G1/S transition of mitotic cell cycle; negative regulation of activin receptor signaling pathway; negative regulation of signal transduction; peptidyl-threonine phosphorylation; positive regulation of bone mineralization; positive regulation of cell migration; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; regulation of ossification; transforming growth factor beta receptor signaling pathway
Disease: Fibrodysplasia Ossificans Progressiva
Research Articles on ACVR1
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Products associated with ACVR1 blocking peptide
Pathways associated with ACVR1 blocking peptide
Diseases associated with ACVR1 blocking peptide
Organs/Tissues associated with ACVR1 blocking peptide
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