NP_000665.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,348 Da
NCBI Official Full Name
adenosine receptor A1
NCBI Official Synonym Full Names
adenosine A1 receptor
NCBI Official Synonym Symbols
NCBI Protein Information
adenosine receptor A1
UniProt Protein Name
Adenosine receptor A1
UniProt Entry Name
AA1R_HUMAN
NCBI Summary for ADORA1
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ADORA1
ADORA1: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GPCR, family 1; Receptor, GPCR; Apoptosis; Membrane protein, integral; Endoplasmic reticulum; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: basolateral plasma membrane; endoplasmic reticulum; integral to plasma membrane; postsynaptic density; dendritic spine; terminal button; axolemma; presynaptic membrane; asymmetric synapse; postsynaptic membrane; cell soma; plasma membrane; presynaptic active zone
Molecular Function: protein binding; G-protein-coupled receptor binding; protein heterodimerization activity; G-protein beta/gamma-subunit binding; adenosine receptor activity, G-protein coupled; purine nucleoside binding; phospholipase C activity; heterotrimeric G-protein binding
Biological Process: negative regulation of circadian sleep/wake cycle, non-REM sleep; relaxation of vascular smooth muscle; negative regulation of glutamate secretion; activation of MAPKK activity; negative regulation of hormone secretion; positive regulation of potassium ion transport; regulation of synaptic plasticity; neurological control of breathing; positive regulation of peptide secretion; thermoregulation; signal transduction; positive regulation of protein amino acid dephosphorylation; negative regulation of cell proliferation; regulation of glomerular filtration; negative regulation of vasodilation; negative regulation of lipid catabolic process; cell-cell signaling; positive regulation of nucleoside transport; positive regulation of epidermal growth factor receptor activity; negative regulation of blood pressure; inflammatory response; protein targeting to membrane; detection of temperature stimulus involved in sensory perception of pain; negative regulation of synaptic transmission, GABAergic; adenosine receptor signaling pathway; nervous system development; negative regulation of neurotrophin production; negative regulation of synaptic transmission, glutamatergic; negative regulation of acute inflammatory response; negative regulation of leukocyte migration; phagocytosis; response to hypoxia; regulation of sensory perception of pain; G-protein signaling, adenylate cyclase inhibiting pathway; cognition; regulation of excitatory postsynaptic membrane potential; lipid catabolic process; positive regulation of blood pressure; negative regulation of apoptosis
Research Articles on ADORA1
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Products associated with ADORA1 blocking peptide
Pathways associated with ADORA1 blocking peptide
Diseases associated with ADORA1 blocking peptide
Organs/Tissues associated with ADORA1 blocking peptide
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