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ADD1 blocking peptide :: Alpha-adducin Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS827754 ADD1 blocking peptide
Unit / Price
1 mg  /  $195 +1 FREE 8GB USB
5 mg  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Alpha-adducin (ADD1), Blocking Peptide

 Also Known As   

Alpha-adducin (pS726/713) Blocking Peptide

 Product Synonym Names    ADD1; ADDA; Alpha-adducin; Erythrocyte adducin subunit alpha; ADD2; ADDB; Beta-adducin; Erythrocyte adducin subunit beta
 Product Gene Name   

ADD1 blocking peptide

[Similar Products]
 Product Synonym Gene Name    ADD2 [Similar Products]
 Antibody/Peptide Pairs    Alpha-adducin peptide (MBS827754) is used for blocking the activity of Alpha-adducin antibody (MBS829952)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    102680
 3D Structure    ModBase 3D Structure for P35611
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 Host    Synthetic
 Species Reactivity    Human, Mouse, Rat, Porcine
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 Purity/Purification    >85%
 Form/Format    Lyophilized powder
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 Quality Control    The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
 Directions for Use    Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Other Notes    Small volumes of ADD1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for ADD1 blocking peptide

   The peptide is used to block Anti-Alpha-adducin Antibody reactivity.
 Applications Tested/Suitable for ADD1 blocking peptide   

Blocking (BL)

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NCBI/Uniprot data below describe general gene information for ADD1. It may not necessarily be applicable to this product.
 NCBI GI #    29826319
 NCBI GeneID    118
 NCBI Accession #    NP_001110.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001119.4 [Other Products]
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 UniProt Primary Accession #    P35611 [Other Products]
 UniProt Secondary Accession #    Q13734; Q14729; Q16156; Q86XM2; Q9UJB6; A2A3N8; A2A3P0; B4DI79; D3DVR3; D3DVR4; D3DVR5 [Other Products]
 UniProt Related Accession #    P35611 [Other Products]
 Molecular Weight    73,333 Da
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 NCBI Official Full Name    alpha-adducin isoform a
 NCBI Official Synonym Full Names    adducin 1 (alpha)
 NCBI Official Symbol    ADD1 [Similar Products]
 NCBI Official Synonym Symbols   
ADDA
[Similar Products]
 NCBI Protein Information    alpha-adducin
 UniProt Protein Name    Alpha-adducin
 UniProt Synonym Protein Names   
Erythrocyte adducin subunit alpha
 Protein Family    Alpha-adducin
 UniProt Gene Name    ADD1 [Similar Products]
 UniProt Synonym Gene Names    ADDA [Similar Products]
 UniProt Entry Name    ADDA_HUMAN
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 NCBI Summary for ADD1    Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADD1    ADD1: a cytoskeletal protein that promotes the assembly of the spectrin-actin network. Adducin is a heterodimeric protein that consists of related subunits. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Three alternatively-spliced isoforms have been described.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: nucleoplasm; F-actin capping protein complex; intermediate filament cytoskeleton; focal adhesion; perinuclear region of cytoplasm; postsynaptic density; plasma membrane; dendritic spine; cytosol; nucleus

Molecular Function: calmodulin binding; actin filament binding; protein homodimerization activity; spectrin binding; protein heterodimerization activity; T cell receptor binding; actin binding; structural molecule activity; transcription factor binding

Biological Process: actin filament bundle formation; positive regulation of protein binding; unfolded protein response; apoptosis; hemoglobin metabolic process; in utero embryonic development; multicellular organism growth; cell morphogenesis; positive regulation of endocytosis; positive regulation of angiogenesis; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; homeostasis of number of cells within a tissue; erythrocyte differentiation; cell volume homeostasis; barbed-end actin filament capping; actin cytoskeleton organization and biogenesis; cell structure disassembly during apoptosis

Disease: Hypertension, Essential
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 Research Articles on ADD1    1. There were significant differences between the control group and pediatric hypertensive group in terms of ACE I/D (P<0.05) and AGT M235T (P<0.05) polymorphisms, but there were no differences in ADD Gly460Trp (P>0.05) polymorphism.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ADD1 blocking peptidePathways associated with ADD1 blocking peptide
 Reference Product  PubMed Publications
 ADD2 blocking peptide  >16 publications with ADD1 and ADD2
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway antibodies  Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway Diagram
 IRE1alpha Activates Chaperones Pathway antibodies  IRE1alpha Activates Chaperones Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Miscellaneous Transport And Binding Events Pathway antibodies  Miscellaneous Transport And Binding Events Pathway Diagram
 Programmed Cell Death Pathway antibodies  Programmed Cell Death Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Unfolded Protein Response (UPR) Pathway antibodies  Unfolded Protein Response (UPR) Pathway Diagram
Diseases associated with ADD1 blocking peptideOrgans/Tissues associated with ADD1 blocking peptide
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >71 publications with ADD1 and Hypertension
 Nervous System Diseases Antibodies  >13 publications with ADD1 and Nervous System Diseases
 Fatty Liver Antibodies  >12 publications with ADD1 and Fatty Liver
 Heart Diseases Antibodies  >12 publications with ADD1 and Heart Diseases
 Brain Diseases Antibodies  >11 publications with ADD1 and Brain Diseases
 Kidney Diseases Antibodies  >6 publications with ADD1 and Kidney Diseases
 Proteinuria Antibodies  >4 publications with ADD1 and Proteinuria
 Congenital Abnormalities Antibodies  >4 publications with ADD1 and Congenital Abnormalities
 Hemorrhage Antibodies  >3 publications with ADD1 and Hemorrhage
 Hypertrophy Antibodies  >2 publications with ADD1 and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >67 publications with ADD1 and Blood
 Adipose Tissue Antibodies  >31 publications with ADD1 and Adipose Tissue
 Connective Tissue Antibodies  >22 publications with ADD1 and Connective Tissue
 Liver Antibodies  >18 publications with ADD1 and Liver
 Muscle Antibodies  >14 publications with ADD1 and Muscle
 Heart Antibodies  >14 publications with ADD1 and Heart
 Kidney Antibodies  >11 publications with ADD1 and Kidney
 Brain Antibodies  >8 publications with ADD1 and Brain
 Nerve Antibodies  >5 publications with ADD1 and Nerve
 Bone Antibodies  >5 publications with ADD1 and Bone
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