NP_001636.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
9,332 Da
NCBI Official Full Name
apolipoprotein C-I
NCBI Official Synonym Full Names
apolipoprotein C-I
NCBI Protein Information
apolipoprotein C-I
UniProt Protein Name
Apolipoprotein C-I
UniProt Synonym Protein Names
Apolipoprotein C1
UniProt Synonym Gene Names
UniProt Entry Name
APOC1_HUMAN
NCBI Summary for APOC1
The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for APOC1
APOC1: Appears to modulate the interaction of APOE with beta- migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification. Belongs to the apolipoprotein C1 family.
Protein type: Secreted; Lipid-binding; Endoplasmic reticulum; Inhibitor; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: chylomicron; endoplasmic reticulum
Molecular Function: phospholipase inhibitor activity; lipase inhibitor activity; phosphatidylcholine binding; fatty acid binding
Biological Process: positive regulation of catalytic activity; cholesterol metabolic process; negative regulation of cholesterol transport; lipoprotein metabolic process; cholesterol efflux; triacylglycerol metabolic process; phospholipid efflux; negative regulation of lipid catabolic process; negative regulation of receptor-mediated endocytosis; negative regulation of lipoprotein lipase activity; lipid metabolic process; regulation of cholesterol transport; negative regulation of lipid metabolic process; negative regulation of fatty acid biosynthetic process
Research Articles on APOC1
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Products associated with APOC1 blocking peptide
Pathways associated with APOC1 blocking peptide
Diseases associated with APOC1 blocking peptide
Organs/Tissues associated with APOC1 blocking peptide
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