Q9QX73.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,156 Da
NCBI Official Full Name
Rho guanine nucleotide exchange factor 9
NCBI Official Synonym Full Names
Cdc42 guanine nucleotide exchange factor 9
NCBI Protein Information
rho guanine nucleotide exchange factor 9
UniProt Protein Name
Rho guanine nucleotide exchange factor 9
UniProt Synonym Protein Names
Collybistin; Rac/Cdc42 guanine nucleotide exchange factor 9
UniProt Entry Name
ARHG9_RAT
UniProt Comments for Arhgef9
ARHGEF9: Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters. Defects in ARHGEF9 are the cause of pileptic encephalopathy, early infantile, type 8 (EIEE8). A disorder characterized by hyperekplexia and early infantile epileptic encephalopathy. Neurologic features include exaggerated startle response, seizures, impaired psychomotor development, and mental retardation. Seizures can be provoked by tactile stimulation or extreme emotion. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs, Rac/Rho; GAPs
Cellular Component: cell cortex; cytoplasm
Molecular Function: protein binding
Biological Process: receptor clustering
Research Articles on Arhgef9
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Diseases associated with Arhgef9 blocking peptide
Organs/Tissues associated with Arhgef9 blocking peptide
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