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ATXN10 blocking peptide :: Ataxin 10 Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS823929 ATXN10 blocking peptide
Unit / Price
1 mg  /  $160 +1 FREE 8GB USB
5 mg  /  $305 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ataxin 10 (ATXN10), Blocking Peptide

 Also Known As   

Ataxin 10 Blocking Peptide

 Product Synonym Names    SCA10; Ataxin-10; Brain protein E46 homolog; Spinocerebellar ataxia type 10 protein
 Product Gene Name   

ATXN10 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    Ataxin 10 peptide (MBS823929) is used for blocking the activity of Ataxin 10 antibody (MBS820427)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 611150
 3D Structure    ModBase 3D Structure for Q9UBB4
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 Host    Synthetic
 Species Reactivity    Human, Mouse, Rat, Monkey
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 Purity/Purification    >85%
 Form/Format    Lyophilized powder
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 Quality Control    The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Other Notes    Small volumes of ATXN10 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for ATXN10 blocking peptide

   The peptide is used to block Anti-Ataxin 10 Antibody reactivity.
 Applications Tested/Suitable for ATXN10 blocking peptide   

Blocking (BL)

 Application Notes for ATXN10 blocking peptide    Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
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NCBI/Uniprot data below describe general gene information for ATXN10. It may not necessarily be applicable to this product.
 NCBI GI #    266453278
 NCBI GeneID    25814
 NCBI Accession #    NP_001161093.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001167621.1 [Other Products]
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 UniProt Primary Accession #    Q9UBB4 [Other Products]
 UniProt Secondary Accession #    O14998; O15009; Q6I9X4; A6NLC4; B4DG05 [Other Products]
 UniProt Related Accession #    Q9UBB4 [Other Products]
 Molecular Weight    46,286 Da
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 NCBI Official Full Name    ataxin-10 isoform 2
 NCBI Official Synonym Full Names    ataxin 10
 NCBI Official Symbol    ATXN10 [Similar Products]
 NCBI Official Synonym Symbols   
E46L; SCA10; HUMEEP
[Similar Products]
 NCBI Protein Information    ataxin-10; brain protein E46 homolog; spinocerebellar ataxia type 10 protein
 UniProt Protein Name    Ataxin-10
 UniProt Synonym Protein Names   
Brain protein E46 homolog; Spinocerebellar ataxia type 10 protein
 Protein Family    Ataxin
 UniProt Gene Name    ATXN10 [Similar Products]
 UniProt Synonym Gene Names    SCA10 [Similar Products]
 UniProt Entry Name    ATX10_HUMAN
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 NCBI Summary for ATXN10    This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of a pentanucleotide repeat in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]
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 UniProt Comments for ATXN10    ataxin-10: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. Defects in ATXN10 are the cause of spinocerebellar ataxia type 10 (SCA10). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA10 is an autosomal dominant cerebellar ataxia (ADCA). Defects in ATXN1 may be a cause of nephronophthisis a chronic tubulo-interstitial nephropathy taht leads to anemia, polyuria, polydipsia, isosthenuria and death in uremia. Belongs to the ataxin-10 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: extracellular space; membrane; cell soma; perinuclear region of cytoplasm; dendrite; cytoplasm; plasma membrane; cytosol

Molecular Function: identical protein binding; protein binding

Biological Process: nervous system development; neurite development

Disease: Spinocerebellar Ataxia 10
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 Research Articles on ATXN10    1. the presence of repeat interruptions in SCA10 repeat expansion may have a role in epilepsy phenotype
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ATXN10 blocking peptideDiseases associated with ATXN10 blocking peptide
 Reference Product  PubMed Publications
 OGT blocking peptide  >2 publications with ATXN10 and OGT
 ATN1 blocking peptide  >1 publications with ATXN10 and ATN1
 PLK1 blocking peptide  >1 publications with ATXN10 and PLK1
 Disease Name  Pubmed Publications
 Spinocerebellar Ataxia 10 Antibodies  >5 publications with ATXN10 and Spinocerebellar Ataxia 10
 Neural Tube Defects Antibodies  >1 publications with ATXN10 and Neural Tube Defects
 Atrophy Antibodies  >1 publications with ATXN10 and Atrophy
 Hyperglycemia Antibodies  >1 publications with ATXN10 and Hyperglycemia
 Kidney Diseases Antibodies  >1 publications with ATXN10 and Kidney Diseases
Organs/Tissues associated with ATXN10 blocking peptide
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >34 publications with ATXN10 and Nerve
 Brain Antibodies  >9 publications with ATXN10 and Brain
 Pancreas Antibodies  >2 publications with ATXN10 and Pancreas
 Kidney Antibodies  >2 publications with ATXN10 and Kidney
 Embryonic Tissue Antibodies  >2 publications with ATXN10 and Embryonic Tissue
 Ganglia Antibodies  >1 publications with ATXN10 and Ganglia
 Muscle Antibodies  >1 publications with ATXN10 and Muscle
 Eye Antibodies  >1 publications with ATXN10 and Eye
 Blood Antibodies  >1 publications with ATXN10 and Blood
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