NP_001177.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
81,958 Da
NCBI Official Full Name
transcription regulator protein BACH1
NCBI Official Synonym Full Names
BTB and CNC homology 1, basic leucine zipper transcription factor 1
NCBI Protein Information
transcription regulator protein BACH1; basic region leucine zipper transcriptional regulator BACH1
UniProt Protein Name
Transcription regulator protein BACH1
UniProt Synonym Protein Names
BTB and CNC homolog 1; HA2303
UniProt Entry Name
BACH1_HUMAN
NCBI Summary for BACH1
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]
UniProt Comments for BACH1
BACH1: a transcriptional regulator that acts as a repressor or activator. Binds, in-vitro, to NF-E2 binding sites on DNA. Plays an important role in coordinating transcription activation and repression by NF-E2. Belongs to the bZIP family, CNC subfamily.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 21q22.11
Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus
Molecular Function: heme binding; transcription factor activity
Biological Process: G1/S-specific transcription in mitotic cell cycle; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; G2/M-specific transcription in mitotic cell cycle
Research Articles on BACH1
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Products associated with BACH1 blocking peptide
Pathways associated with BACH1 blocking peptide
Diseases associated with BACH1 blocking peptide
Organs/Tissues associated with BACH1 blocking peptide
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