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TNFSF13B blocking peptide :: BAFF Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS152973 TNFSF13B blocking peptide
Unit / Price
0.05 mg  /  $140 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BAFF (TNFSF13B), Blocking Peptide

 Also Known As   

BAFF Peptide

 Product Synonym Names    DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20; UNQ401/PRO738; Tumor necrosis factor ligand superfamily member 13B; B lymphocyte stimulator; tumor necrosis factor (ligand) superfamily, member 13b
 Product Gene Name   

TNFSF13B blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    BAFF peptide (MBS152973) is used for blocking the activity of BAFF antibody (MBS150169)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Western Blot Protocol    Western Blot Peptide Blocking Protocol
 OMIM    603969
 3D Structure    ModBase 3D Structure for Q9Y275
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 Form/Format    Liquid
 Concentration    200 ug/mL (lot specific)
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 Species    Human
 Buffer    PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
 Location    16 amino acids near the carboxy terminus of human BAFF.
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 Preparation and Storage    Store BAFF peptide at -20 degree C, stable for one year.
 Other Notes    Small volumes of TNFSF13B blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for TNFSF13B blocking peptide   

Blocking (BL)

 Application Notes for TNFSF13B blocking peptide    BAFF peptide is used for blocking the activity of BAFF antibody.
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NCBI/Uniprot data below describe general gene information for TNFSF13B. It may not necessarily be applicable to this product.
 NCBI GI #    5730097
 NCBI GeneID    10673
 NCBI Accession #    NP_006564 [Other Products]
 NCBI GenBank Nucleotide #    NM_006573.4 [Other Products]
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 UniProt Primary Accession #    Q9Y275 [Other Products]
 UniProt Secondary Accession #    Q6FHD6; Q7Z5J2; E0ADT7 [Other Products]
 UniProt Related Accession #    Q9Y275 [Other Products]
 Molecular Weight    17,578 Da
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 NCBI Official Full Name    tumor necrosis factor ligand superfamily member 13B isoform 1
 NCBI Official Synonym Full Names    tumor necrosis factor (ligand) superfamily, member 13b
 NCBI Official Symbol    TNFSF13B [Similar Products]
 NCBI Official Synonym Symbols   
DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20
[Similar Products]
 NCBI Protein Information    tumor necrosis factor ligand superfamily member 13B; delta BAFF; Delta4 BAFF; B-lymphocyte stimulator; B-cell-activating factor; ApoL related ligand TALL-1; TNF homolog that activates apoptosis; dendritic cell-derived TNF-like molecule; tumor necrosis factor-like protein ZTNF4; TNF and ApoL-related leukocyte expressed ligand 1; tumor necrosis factor (ligand) superfamily, member 20
 UniProt Protein Name    Tumor necrosis factor ligand superfamily member 13B
 UniProt Synonym Protein Names   
B lymphocyte stimulator; BLyS; B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1; TALL-1; CD_antigen: CD257Cleaved into the following 2 chains:Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form
 Protein Family    Tumor necrosis factor ligand superfamily
 UniProt Gene Name    TNFSF13B [Similar Products]
 UniProt Synonym Gene Names    BAFF; BLYS; TALL1; TNFSF20; ZTNF4; BLyS; TALL-1 [Similar Products]
 UniProt Entry Name    TN13B_HUMAN
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 NCBI Summary for TNFSF13B    The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
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 UniProt Comments for TNFSF13B    BAFF: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Membrane protein, integral; Apoptosis; Cytokine

Chromosomal Location of Human Ortholog: 13q32-q34

Cellular Component: extracellular space; perinuclear region of cytoplasm; cytoplasm; integral to membrane; plasma membrane

Molecular Function: protein binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: cell proliferation; B cell costimulation; B cell homeostasis; immunoglobulin secretion; positive regulation of cell proliferation; T cell costimulation; positive regulation of germinal center formation; positive regulation of B cell proliferation; positive regulation of T cell proliferation; immune response; signal transduction
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 Research Articles on TNFSF13B    1. Availability of BAFF determines BAFF-R and TACI expression on B cells in common variable immunodeficiency.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TNFSF13B blocking peptidePathways associated with TNFSF13B blocking peptide
 Reference Product  PubMed Publications
 TNFRSF13C blocking peptide  >121 publications with TNFSF13B and TNFRSF13C
 TNFRSF17 blocking peptide  >104 publications with TNFSF13B and TNFRSF17
 TNFRSF13B blocking peptide  >78 publications with TNFSF13B and TNFRSF13B
 IL6 blocking peptide  >13 publications with TNFSF13B and IL6
 AICDA blocking peptide  >6 publications with TNFSF13B and AICDA
 IFNG blocking peptide  >2 publications with TNFSF13B and IFNG
 CD40LG blocking peptide  >1 publications with TNFSF13B and CD40LG
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
Diseases associated with TNFSF13B blocking peptideOrgans/Tissues associated with TNFSF13B blocking peptide
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >449 publications with TNFSF13B and Necrosis
 Inflammation Antibodies  >77 publications with TNFSF13B and Inflammation
 Nervous System Diseases Antibodies  >54 publications with TNFSF13B and Nervous System Diseases
 Kidney Diseases Antibodies  >31 publications with TNFSF13B and Kidney Diseases
 Skin Diseases Antibodies  >25 publications with TNFSF13B and Skin Diseases
 Liver Diseases Antibodies  >14 publications with TNFSF13B and Liver Diseases
 Bone Marrow Diseases Antibodies  >13 publications with TNFSF13B and Bone Marrow Diseases
 Thrombocytopenia Antibodies  >12 publications with TNFSF13B and Thrombocytopenia
 Hyperplasia Antibodies  >10 publications with TNFSF13B and Hyperplasia
 Leukopenia Antibodies  >8 publications with TNFSF13B and Leukopenia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >602 publications with TNFSF13B and Blood
 Bone Marrow Antibodies  >68 publications with TNFSF13B and Bone Marrow
 Lymph Node Antibodies  >46 publications with TNFSF13B and Lymph Node
 Kidney Antibodies  >36 publications with TNFSF13B and Kidney
 Skin Antibodies  >18 publications with TNFSF13B and Skin
 Vascular Antibodies  >14 publications with TNFSF13B and Vascular
 Liver Antibodies  >13 publications with TNFSF13B and Liver
 Brain Antibodies  >12 publications with TNFSF13B and Brain
 Thymus Antibodies  >8 publications with TNFSF13B and Thymus
 Pharynx Antibodies  >8 publications with TNFSF13B and Pharynx
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