NP_036474.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
29,108 Da
NCBI Official Full Name
BMP and activin membrane-bound inhibitor homolog
NCBI Official Synonym Full Names
BMP and activin membrane-bound inhibitor
NCBI Official Synonym Symbols
NCBI Protein Information
BMP and activin membrane-bound inhibitor homolog
UniProt Protein Name
BMP and activin membrane-bound inhibitor homolog
UniProt Synonym Protein Names
Non-metastatic gene A protein; Putative transmembrane protein NMA
UniProt Synonym Gene Names
UniProt Entry Name
BAMBI_HUMAN
NCBI Summary for BAMBI
This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]
UniProt Comments for BAMBI
BAMBI: Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.
Protein type: Membrane protein, integral; Inhibitor
Chromosomal Location of Human Ortholog: 10p12.3-p11.2
Cellular Component: cytoplasm; plasma membrane; integral to membrane
Molecular Function: frizzled binding; punt binding
Biological Process: regulation of cell shape; cell migration; positive regulation of protein binding; positive regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway
Research Articles on BAMBI
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Products associated with BAMBI blocking peptide
Pathways associated with BAMBI blocking peptide
Diseases associated with BAMBI blocking peptide
Organs/Tissues associated with BAMBI blocking peptide
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