AAH05942
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,059 Da
NCBI Official Full Name
Barrier to autointegration factor 1
NCBI Official Synonym Full Names
barrier to autointegration factor 1
NCBI Protein Information
barrier-to-autointegration factor; breakpoint cluster region protein 1
UniProt Protein Name
Barrier-to-autointegration factor
UniProt Synonym Protein Names
Breakpoint cluster region protein 1Barrier-to-autointegration factor, N-terminally processed
UniProt Synonym Gene Names
UniProt Entry Name
BAF_HUMAN
NCBI Summary for BANF1
The protein encoded by this gene was first identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The protein forms a homodimer which localizes to both the nucleus and cytoplasm and is specifically associated with chromosomes during mitosis. This protein binds to double stranded DNA in a non-specific manner and also binds to LEM-domain containing proteins of the nuclear envelope. This protein is thought to facilitate nuclear reassembly by binding with both DNA and inner nuclear membrane proteins and thereby recruit chromatin to the nuclear periphery. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Jan 2009]
UniProt Comments for BANF1
BAF: Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging. Exploited by retroviruses for inhibiting self- destructing autointegration of retroviral DNA, thereby promoting integration of viral DNA into the host chromosome. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Defects in BANF1 are the cause of Nestor-Guillermo progeria syndrome (NGPS). NGPS is an atypical progeroid syndrome characterized by normal development in the first years of life, later followed by the emergence of generalized lipoatrophy, severe osteoporosis, and marked osteolysis. The atrophic facial subcutaneous fat pad and the marked osteolysis of the maxilla and mandible result in a typical pseudosenile facial appearance with micrognatia, prominent subcutaneous venous patterning, a convex nasal ridge, and proptosis. Cognitive development is completely normal. Patients do not have cardiovascular dysfunction, atherosclerosis, or metabolic anomalies. Belongs to the BAF family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: nucleoplasm; cytoplasm; chromosome; cytosol; nucleus
Molecular Function: protein binding; DNA binding
Biological Process: mitotic nuclear envelope reassembly; viral reproduction; DNA integration; response to virus; mitotic nuclear envelope disassembly; mitotic cell cycle
Disease: Nestor-guillermo Progeria Syndrome
Research Articles on BANF1
Precautions
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Products associated with BANF1 blocking peptide
Pathways associated with BANF1 blocking peptide
Diseases associated with BANF1 blocking peptide
Organs/Tissues associated with BANF1 blocking peptide
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