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BCL10 blocking peptide :: BCL-10 Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS152141
Western Blot (WB)
Unit / Price
0.05 mg  /  $135 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BCL-10 (BCL10), Blocking Peptide

 Also Known As   

BCL-10 Peptide

 Product Synonym Names    CLAP; mE10; CIPER; c-E10; CARMEN; CLAP; CARD-containing molecule enhancing NF-kappa-B; Bcl-10; B-cell CLL/lymphoma 10
 Product Gene Name   

BCL10 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    BCL-10 peptide (MBS152141) is used for blocking the activity of Bcl-10 antibody (MBS150410)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Western Blot Protocol    Western Blot Peptide Blocking Protocol
 OMIM    phenotype 603517
 3D Structure    ModBase 3D Structure for O95999
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 Form/Format    Liquid
 Concentration    200 ug/mL (lot specific)
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 Species    Human
 Buffer    PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
 Location    15 amino amino terminus of human BCL-10.
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 Preparation and Storage    Store BCL-10 peptide at -20 degree C, stable for one year.
 Other Notes    Small volumes of BCL10 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for BCL10 blocking peptide   

Blocking (BL)

 Application Notes for BCL10 blocking peptide    BCL-10 peptide is used for blocking the activity of BCL-10 antibody.
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 Western Blot (WB) of BCL10 blocking peptide    Western blot analysis of Bcl-10 in Raji whole cell lysate in the absence (A) or presence (B) of peptide (2161P) with Bcl-10 antibody at 1:500 dilution.
BCL10 blocking peptide Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for BCL10. It may not necessarily be applicable to this product.
 NCBI GI #    5070371
 NCBI GeneID    8915
 NCBI Accession #    AF134395 [Other Products]
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 UniProt Primary Accession #    O95999 [Other Products]
 UniProt Secondary Accession #    Q5VUF1 [Other Products]
 UniProt Related Accession #    O95999 [Other Products]
 Molecular Weight    26,252 Da
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 NCBI Official Full Name    Homo sapiens CARD-like apoptotic protein (CLAP) mRNA, complete cds
 NCBI Official Synonym Full Names    B-cell CLL/lymphoma 10
 NCBI Official Symbol    BCL10 [Similar Products]
 NCBI Official Synonym Symbols   
CLAP; mE10; CIPER; IMD37; c-E10; CARMEN
[Similar Products]
 NCBI Protein Information    B-cell lymphoma/leukemia 10; hCLAP; cCARMEN; cellular-E10; cellular homolog of vCARMEN; CARD-containing proapoptotic protein; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; caspase-recruiting domain-containing protein; CARD-containing molecule enhancing NF-kappa-B; mammalian CARD-containing adapter molecule E10; CED-3/ICH-1 prodomain homologous E10-like regulator
 UniProt Protein Name    B-cell lymphoma/leukemia 10
 UniProt Synonym Protein Names   
B-cell CLL/lymphoma 10; Bcl-10; CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein; hCLAP; CED-3/ICH-1 prodomain homologous E10-like regulator; CIPER; Cellular homolog of vCARMEN; cCARMEN; Cellular-E10; c-E10; Mammalian CARD-containing adapter molecule E10; mE10
 Protein Family    B-cell lymphoma/leukemia
 UniProt Gene Name    BCL10 [Similar Products]
 UniProt Synonym Gene Names    CIPER; CLAP; Bcl-10; hCLAP; CIPER; cCARMEN; c-E10; mE10 [Similar Products]
 UniProt Entry Name    BCL10_HUMAN
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 NCBI Summary for BCL10    This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BCL10    Bcl-10: a ubiquitous pro-apoptotic protein that promotes pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Self-associates via CARD-CARD interactions; forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Defects in BCL10 are involved in various types of cancer.

Protein type: Tumor suppressor; Transcription, coactivator/corepressor; Apoptosis

Chromosomal Location of Human Ortholog: 1p22

Cellular Component: CBM complex; protein complex; lysosome; immunological synapse; cytosol; lipid raft; T cell receptor complex; perinuclear region of cytoplasm; cytoplasmic microtubule; cytoplasm; plasma membrane; lipopolysaccharide receptor complex; nucleus

Molecular Function: protein C-terminus binding; protein kinase B binding; ubiquitin binding; protein self-association; protease binding; transcription coactivator activity; transcription factor binding; protein kinase binding; NF-kappaB binding; protein binding; enzyme binding; ubiquitin protein ligase binding; kinase activator activity; kinase binding

Biological Process: cell death; response to fungus; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; B cell apoptosis; T cell receptor signaling pathway; interleukin-6 biosynthetic process; activation of NF-kappaB transcription factor; negative regulation of mature B cell apoptosis; response to molecule of bacterial origin; protein homooligomerization; response to food; adaptive immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-8 biosynthetic process; protein oligomerization; positive regulation of protein ubiquitination; regulation of T cell receptor signaling pathway; lymphotoxin A biosynthetic process; neural tube closure; toll-like receptor signaling pathway; cellular defense response; innate immune response; immunoglobulin mediated immune response; positive regulation of T cell activation; positive regulation of mast cell cytokine production; positive regulation of phosphorylation

Disease: Follicular Lymphoma, Susceptibility To, 1; Mesothelioma, Malignant; Gastric Lymphoma, Primary; Testicular Germ Cell Tumor; Immunodeficiency 37
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 Research Articles on BCL10    1. BCL10 delivers UBC13 to RNF8/RNF168 to regulate ubiquitination-mediated double-strand break signaling and repair.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BCL10 blocking peptidePathways associated with BCL10 blocking peptide
 Reference Product  PubMed Publications
 MALT1 blocking peptide  >223 publications with BCL10 and MALT1
 CARD11 blocking peptide  >98 publications with BCL10 and CARD11
 IKBKB blocking peptide  >55 publications with BCL10 and IKBKB
 CARD9 blocking peptide  >32 publications with BCL10 and CARD9
 CARD10 blocking peptide  >20 publications with BCL10 and CARD10
 TRAF6 blocking peptide  >18 publications with BCL10 and TRAF6
 IKBKG blocking peptide  >7 publications with BCL10 and IKBKG
 CARD14 blocking peptide  >6 publications with BCL10 and CARD14
 RIPK2 blocking peptide  >5 publications with BCL10 and RIPK2
 BIRC3 blocking peptide  >1 publications with BCL10 and BIRC3
 Products by Pathway  Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 FCERI Mediated NF-kB Activation Pathway antibodies  FCERI Mediated NF-kB Activation Pathway Diagram
Diseases associated with BCL10 blocking peptideOrgans/Tissues associated with BCL10 blocking peptide
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >199 publications with BCL10 and Immune System Diseases
 Inflammation Antibodies  >42 publications with BCL10 and Inflammation
 Necrosis Antibodies  >38 publications with BCL10 and Necrosis
 Adenocarcinoma Antibodies  >16 publications with BCL10 and Adenocarcinoma
 Nervous System Diseases Antibodies  >12 publications with BCL10 and Nervous System Diseases
 Lung Diseases Antibodies  >11 publications with BCL10 and Lung Diseases
 Cardiovascular Diseases Antibodies  >11 publications with BCL10 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >9 publications with BCL10 and Breast Neoplasms
 Lung Neoplasms Antibodies  >9 publications with BCL10 and Lung Neoplasms
 Brain Diseases Antibodies  >8 publications with BCL10 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >136 publications with BCL10 and Blood
 Stomach Antibodies  >41 publications with BCL10 and Stomach
 Intestine Antibodies  >18 publications with BCL10 and Intestine
 Lung Antibodies  >18 publications with BCL10 and Lung
 Liver Antibodies  >15 publications with BCL10 and Liver
 Lymph Node Antibodies  >15 publications with BCL10 and Lymph Node
 Spleen Antibodies  >14 publications with BCL10 and Spleen
 Skin Antibodies  >13 publications with BCL10 and Skin
 Bone Antibodies  >13 publications with BCL10 and Bone
 Bone Marrow Antibodies  >12 publications with BCL10 and Bone Marrow
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