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BMPR2 blocking peptide

Scan QR to view Datasheet Catalog #    MBS824359 BMPR2 blocking peptide
Unit / Price
1 mg  /  $160 +1 FREE 8GB USB
5 mg  /  $305 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BMPR2, Blocking Peptide

 Also Known As   

BMPR2 Blocking Peptide

 Product Synonym Names    PPH1; Bone morphogenetic protein receptor type-2; BMP type-2 receptor; BMPR-2; Bone morphogenetic protein receptor type II; BMP type II receptor; BMPR-II
 Product Gene Name   

BMPR2 blocking peptide

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
 Antibody/Peptide Pairs    BMPR2 peptide (MBS824359) is used for blocking the activity of BMPR2 antibody (MBS820340)
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 OMIM    phenotype 600799
 3D Structure    ModBase 3D Structure for Q13873
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 Host    Synthetic
 Species Reactivity    Human, Mouse, Rat, Pig
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 Purity/Purification    >85%
 Form/Format    Lyophilized powder
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 Quality Control    The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Other Notes    Small volumes of BMPR2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for BMPR2 blocking peptide

   The peptide is used to block Anti-BMPR2 Antibody reactivity.
 Applications Tested/Suitable for BMPR2 blocking peptide   

Blocking (BL)

 Application Notes for BMPR2 blocking peptide    Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
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NCBI/Uniprot data below describe general gene information for BMPR2. It may not necessarily be applicable to this product.
 NCBI GI #    15451916
 NCBI GeneID    659
 NCBI Accession #    NP_001195.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001204.6 [Other Products]
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 UniProt Primary Accession #    Q13873 [Other Products]
 UniProt Secondary Accession #    Q13161; Q16569; Q4ZG08; Q53SA5; Q585T8 [Other Products]
 UniProt Related Accession #    Q13873 [Other Products]
 Molecular Weight    59,963 Da
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 NCBI Official Full Name    bone morphogenetic protein receptor type-2
 NCBI Official Synonym Full Names    bone morphogenetic protein receptor, type II (serine/threonine kinase)
 NCBI Official Symbol    BMPR2 [Similar Products]
 NCBI Official Synonym Symbols   
BMR2; PPH1; BMPR3; BRK-3; POVD1; T-ALK; BMPR-II
[Similar Products]
 NCBI Protein Information    bone morphogenetic protein receptor type-2; BMPR-2; BMP type-2 receptor; BMP type II receptor; type II activin receptor-like kinase; bone morphogenetic protein receptor type II; type II receptor for bone morphogenetic protein-4
 UniProt Protein Name    Bone morphogenetic protein receptor type-2
 UniProt Synonym Protein Names   
Bone morphogenetic protein receptor type II; BMP type II receptor; BMPR-II
 Protein Family    Bone morphogenetic protein receptor
 UniProt Gene Name    BMPR2 [Similar Products]
 UniProt Synonym Gene Names    PPH1; BMP type-2 receptor; BMPR-2; BMP type II receptor; BMPR-II [Similar Products]
 UniProt Entry Name    BMPR2_HUMAN
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 NCBI Summary for BMPR2    This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BMPR2    BMPR2: a serine/threonine-protein kinase receptor for bone morphogenetic protein (BMP). Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Defects in BMPR2 are the cause of primary pulmonary hypertension (PPH1), a weakly penetrant dominant disorder, associated with lesions in pulmonary arterioles, elevated pulmonary arterial pressure, and right ventricular failure.

Protein type: Cell cycle regulation; Protein kinase, Ser/Thr (receptor); Kinase, protein; Membrane protein, integral; EC 2.7.11.30; Protein kinase, TKL; TKL group; STKR family; Type2 subfamily

Chromosomal Location of Human Ortholog: 2q33-q34

Cellular Component: extracellular space; cell surface; cell soma; integral to plasma membrane; cytoplasm; dendrite; apical plasma membrane; basal plasma membrane; plasma membrane; caveola

Molecular Function: transforming growth factor beta receptor activity; protein binding; growth factor binding; metal ion binding; activin receptor activity, type II; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: limb development; transcription from RNA polymerase II promoter; regulation of lung blood pressure; negative regulation of systemic arterial blood pressure; activin receptor signaling pathway; chondrocyte development; cellular response to starvation; positive regulation of bone mineralization; protein amino acid phosphorylation; negative regulation of vasoconstriction; regulation of cell proliferation; anterior/posterior pattern formation; BMP signaling pathway; positive regulation of osteoblast differentiation; mesoderm formation; proteoglycan biosynthetic process; transmembrane receptor protein serine/threonine kinase signaling pathway; lymphangiogenesis; positive regulation of axon extension involved in axon guidance; blood vessel remodeling; positive regulation of endothelial cell proliferation; negative regulation of cell growth; brain development; vascular endothelial growth factor receptor signaling pathway; alveolus development; positive regulation of BMP signaling pathway

Disease: Pulmonary Venoocclusive Disease 1, Autosomal Dominant; Pulmonary Hypertension, Primary, 1
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 Research Articles on BMPR2    1. BMP type II receptors, BMPR2 and ActR2a, have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BMPR2 blocking peptidePathways associated with BMPR2 blocking peptide
 Reference Product  PubMed Publications
 BMPR1A blocking peptide  >280 publications with BMPR2 and BMPR1A
 BMP2 blocking peptide  >205 publications with BMPR2 and BMP2
 BMP4 blocking peptide  >152 publications with BMPR2 and BMP4
 BMP7 blocking peptide  >118 publications with BMPR2 and BMP7
 BMPR1B blocking peptide  >98 publications with BMPR2 and BMPR1B
 BMP6 blocking peptide  >58 publications with BMPR2 and BMP6
 ACVR1 blocking peptide  >35 publications with BMPR2 and ACVR1
 SMAD6 blocking peptide  >27 publications with BMPR2 and SMAD6
 GDF5 blocking peptide  >25 publications with BMPR2 and GDF5
 GDF2 blocking peptide  >16 publications with BMPR2 and GDF2
 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 ALK2 Signaling Events Pathway antibodies  ALK2 Signaling Events Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 BMP Signalling And Regulation Pathway antibodies  BMP Signalling And Regulation Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Id Signaling Pathway antibodies  Id Signaling Pathway Diagram
Diseases associated with BMPR2 blocking peptideOrgans/Tissues associated with BMPR2 blocking peptide
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >425 publications with BMPR2 and Hypertension
 Hypertension, Pulmonary Antibodies  >424 publications with BMPR2 and Hypertension, Pulmonary
 Lung Diseases Antibodies  >361 publications with BMPR2 and Lung Diseases
 Cardiovascular Diseases Antibodies  >103 publications with BMPR2 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >71 publications with BMPR2 and Disease Models, Animal
 Heart Diseases Antibodies  >58 publications with BMPR2 and Heart Diseases
 Inflammation Antibodies  >56 publications with BMPR2 and Inflammation
 Hypertrophy Antibodies  >54 publications with BMPR2 and Hypertrophy
 Nervous System Diseases Antibodies  >31 publications with BMPR2 and Nervous System Diseases
 Necrosis Antibodies  >19 publications with BMPR2 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1157 publications with BMPR2 and Bone
 Vascular Antibodies  >321 publications with BMPR2 and Vascular
 Muscle Antibodies  >193 publications with BMPR2 and Muscle
 Lung Antibodies  >167 publications with BMPR2 and Lung
 Heart Antibodies  >142 publications with BMPR2 and Heart
 Blood Antibodies  >140 publications with BMPR2 and Blood
 Embryonic Tissue Antibodies  >78 publications with BMPR2 and Embryonic Tissue
 Connective Tissue Antibodies  >73 publications with BMPR2 and Connective Tissue
 Ovary Antibodies  >70 publications with BMPR2 and Ovary
 Bone Marrow Antibodies  >43 publications with BMPR2 and Bone Marrow
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