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BPI blocking peptide

Scan QR to view Datasheet Catalog #    MBS9227995 BPI blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BPI, Blocking Peptide

★Popular Item★
 Also Known As   

BPI Antibody (Center) Blocking Peptide

 Product Synonym Names    Bactericidal permeability-increasing protein; BPI; CAP 57; BPI
 Product Gene Name   

BPI blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    BPI peptide (MBS9227995) is used for blocking the activity of BPI antibody (MBS9210718)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    109195
 3D Structure    ModBase 3D Structure for P17213
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 Clone Number    80311208
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 Specificity    The synthetic peptide sequence used to generate the antibody was selected from the Center region of human BPI. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
 Form/Format    Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
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 Cellular Location    Secreted. Cytoplasmic granule membrane. Note: Membrane-associated in polymorphonuclear Leukocytes (PMN) granules
 Function    The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
 Tissue Location    Restricted to cells of the myeloid series.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of BPI blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for BPI blocking peptide

   BPI encodes a lipopolysaccaride binding protein. It is associated with human neutrophil granules and has a bactericidal activity on gram-negative organisms.
NCBI/Uniprot data below describe general gene information for BPI. It may not necessarily be applicable to this product.
 NCBI GI #    215274242
 NCBI GeneID    671
 NCBI Accession #    P17213.4 [Other Products]
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 UniProt Primary Accession #    P17213 [Other Products]
 UniProt Secondary Accession #    Q1ZZU8; Q5JRW0; Q8IW58; Q9BYZ9; Q9H1L2; Q9H1M8; Q9H203; Q9UCT4; Q9UD65; B2RCY2 [Other Products]
 UniProt Related Accession #    P17213 [Other Products]
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 NCBI Official Full Name    Bactericidal permeability-increasing protein
 NCBI Official Synonym Full Names    bactericidal/permeability-increasing protein
 NCBI Official Symbol    BPI [Similar Products]
 NCBI Official Synonym Symbols   
rBPI; BPIFD1
[Similar Products]
 NCBI Protein Information    bactericidal permeability-increasing protein
 UniProt Protein Name    Bactericidal permeability-increasing protein
 UniProt Synonym Protein Names   
CAP 57
 Protein Family    BPI fold-containing family
 UniProt Gene Name    BPI [Similar Products]
 UniProt Synonym Gene Names    BPI [Similar Products]
 UniProt Entry Name    BPI_HUMAN
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 NCBI Summary for BPI    This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]
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 UniProt Comments for BPI    BPI: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Protein type: Cell surface; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q11.23

Cellular Component: integral to plasma membrane

Molecular Function: lipopolysaccharide binding

Biological Process: negative regulation of interleukin-6 production; negative regulation of interleukin-8 production; negative regulation of macrophage activation; negative regulation of tumor necrosis factor production
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 Research Articles on BPI    1. Bactericidal permeability increasing protein Lys216Glu polymorphism is associated with both Crohn's disease and ulcerative colitis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BPI blocking peptidePathways associated with BPI blocking peptide
 Reference Product  PubMed Publications
 BPIFA1 blocking peptide  >27 publications with BPI and BPIFA1
 CTSG blocking peptide  >10 publications with BPI and CTSG
 BPIFA2 blocking peptide  >5 publications with BPI and BPIFA2
 CAMP blocking peptide  >3 publications with BPI and CAMP
 AZU1 blocking peptide  >2 publications with BPI and AZU1
 PRTN3 blocking peptide  >2 publications with BPI and PRTN3
 CEBPE blocking peptide  >2 publications with BPI and CEBPE
 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Toll Like Receptor 4 (TLR4) Cascade Pathway antibodies  Toll Like Receptor 4 (TLR4) Cascade Pathway Diagram
 Toll-Like Receptors Cascades Pathway antibodies  Toll-Like Receptors Cascades Pathway Diagram
Diseases associated with BPI blocking peptideOrgans/Tissues associated with BPI blocking peptide
 Disease Name  Pubmed Publications
 Pain Antibodies  >565 publications with BPI and Pain
 Inflammation Antibodies  >123 publications with BPI and Inflammation
 Necrosis Antibodies  >79 publications with BPI and Necrosis
 Depressive Disorder Antibodies  >64 publications with BPI and Depressive Disorder
 Fibrosis Antibodies  >41 publications with BPI and Fibrosis
 Disease Models, Animal Antibodies  >34 publications with BPI and Disease Models, Animal
 Neurobehavioral Manifestations Antibodies  >22 publications with BPI and Neurobehavioral Manifestations
 Heart Diseases Antibodies  >17 publications with BPI and Heart Diseases
 Kidney Diseases Antibodies  >16 publications with BPI and Kidney Diseases
 Cognition Disorders Antibodies  >15 publications with BPI and Cognition Disorders
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >515 publications with BPI and Blood
 Bone Antibodies  >100 publications with BPI and Bone
 Brain Antibodies  >100 publications with BPI and Brain
 Liver Antibodies  >44 publications with BPI and Liver
 Kidney Antibodies  >35 publications with BPI and Kidney
 Heart Antibodies  >31 publications with BPI and Heart
 Bone Marrow Antibodies  >17 publications with BPI and Bone Marrow
 Connective Tissue Antibodies  >6 publications with BPI and Connective Tissue
 Ovary Antibodies  >6 publications with BPI and Ovary
 Thyroid Antibodies  >4 publications with BPI and Thyroid
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