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CADPS2 blocking peptide :: CAPS2 Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS152077 CADPS2 blocking peptide
Unit / Price
0.05 mg  /  $135 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CAPS2 (CADPS2), Blocking Peptide

 Also Known As   

CAPS2 Peptide

 Product Synonym Names    CAPS2; KIAA1591; Calcium-dependent secretion activator 2; Calcium-dependent activator protein for secretion 2; CAPS-2; Ca++-dependent secretion activator 2
 Product Gene Name   

CADPS2 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    CAPS2 peptide (MBS152077) is used for blocking the activity of CAPS2 antibody (MBS150554)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Western Blot Protocol    Western Blot Peptide Blocking Protocol
 OMIM    609978
 3D Structure    ModBase 3D Structure for Q86UW7
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 Form/Format    Liquid
 Concentration    200 ug/mL (lot specific)
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 Species    Human
 Buffer    PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
 Location    19 amino acids near the center of human CAPS2.
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 Preparation and Storage    Store CAPS2 peptide at -20 degree C, stable for one year.
 Other Notes    Small volumes of CADPS2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for CADPS2 blocking peptide   

Blocking (BL)

 Application Notes for CADPS2 blocking peptide    CAPS2 peptide is used for blocking the activity of CAPS2 antibody.
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NCBI/Uniprot data below describe general gene information for CADPS2. It may not necessarily be applicable to this product.
 NCBI GI #    148839294
 NCBI GeneID    93664
 NCBI Accession #    NP_060424 [Other Products]
 NCBI GenBank Nucleotide #    NM_017954.10 [Other Products]
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 UniProt Primary Accession #    Q86UW7 [Other Products]
 UniProt Secondary Accession #    Q658Q2; Q7Z5T7; Q8IZW9; Q8N7M4; Q9H6P4; Q9HCI1; Q9NWK8; A4D0X3; B7ZM56 [Other Products]
 UniProt Related Accession #    Q86UW7 [Other Products]
 Molecular Weight    142,883 Da
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 NCBI Official Full Name    calcium-dependent secretion activator 2 isoform a
 NCBI Official Synonym Full Names    Ca++-dependent secretion activator 2
 NCBI Official Symbol    CADPS2 [Similar Products]
 NCBI Protein Information    calcium-dependent secretion activator 2; CAPS-2; Ca2+-dependent activator protein for secretion 2; calcium-dependent activator protein for secretion 2
 UniProt Protein Name    Calcium-dependent secretion activator 2
 UniProt Synonym Protein Names   
Calcium-dependent activator protein for secretion 2; CAPS-2
 Protein Family    Calcium-dependent secretion activator
 UniProt Gene Name    CADPS2 [Similar Products]
 UniProt Synonym Gene Names    CAPS2; KIAA1591; CAPS-2 [Similar Products]
 UniProt Entry Name    CAPS2_HUMAN
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 NCBI Summary for CADPS2    This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
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 UniProt Comments for CADPS2    CADPS2: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)- dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 7q31.3

Cellular Component: presynaptic membrane; postsynaptic membrane; cytoplasmic vesicle membrane; cell junction

Molecular Function: metal ion binding; lipid binding

Biological Process: protein transport; cellular response to starvation; synaptic vesicle priming; positive regulation of exocytosis
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 Research Articles on CADPS2    1. Mutation screening of 187 patients with autism spectrum disorders and 36 with intellectual disability identified a missense change of maternal origin disrupting CADPS2/D2DR interaction.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with CADPS2 blocking peptideOrgans/Tissues associated with CADPS2 blocking peptide
 Disease Name  Pubmed Publications
 Autistic Disorder Antibodies  >8 publications with CADPS2 and Autistic Disorder
 Nervous System Diseases Antibodies  >5 publications with CADPS2 and Nervous System Diseases
 Disease Models, Animal Antibodies  >5 publications with CADPS2 and Disease Models, Animal
 Congenital Abnormalities Antibodies  >1 publications with CADPS2 and Congenital Abnormalities
 Inflammation Antibodies  >1 publications with CADPS2 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15 publications with CADPS2 and Brain
 Nerve Antibodies  >10 publications with CADPS2 and Nerve
 Thyroid Antibodies  >1 publications with CADPS2 and Thyroid
 Thymus Antibodies  >1 publications with CADPS2 and Thymus
 Salivary Gland Antibodies  >1 publications with CADPS2 and Salivary Gland
 Spleen Antibodies  >1 publications with CADPS2 and Spleen
 Kidney Antibodies  >1 publications with CADPS2 and Kidney
 Stomach Antibodies  >1 publications with CADPS2 and Stomach
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