Q14953.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
33,644 Da
NCBI Official Full Name
Killer cell immunoglobulin-like receptor 2DS5
NCBI Official Synonym Full Names
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5
NCBI Protein Information
killer cell immunoglobulin-like receptor 2DS5; NKAT-9; MHC class I NK cell receptor; CD158 antigen-like family member G; natural killer-associated transcript 9; natural killer cell inhibitory receptor
UniProt Protein Name
Killer cell immunoglobulin-like receptor 2DS5
UniProt Synonym Protein Names
CD158 antigen-like family member G; MHC class I NK cell receptor; Natural killer-associated transcript 9; NKAT-9; CD_antigen: CD158g
UniProt Synonym Gene Names
UniProt Entry Name
KI2S5_HUMAN
NCBI Summary for KIR2DS5
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
UniProt Comments for KIR2DS5
KIR2DS5: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. Belongs to the immunoglobulin superfamily.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.4
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: HLA-C specific inhibitory MHC class I receptor activity
Biological Process: innate immune response; immune response; signal transduction
Research Articles on KIR2DS5
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Pathways associated with KIR2DS5 blocking peptide
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