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CDC37 blocking peptide

Scan QR to view Datasheet Catalog #    MBS9227948 CDC37 blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CDC37, Blocking Peptide

 Also Known As   

CDC37 Antibody (Center) Blocking Peptide

 Product Synonym Names    Hsp90 co-chaperone Cdc37; Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37; Hsp90 co-chaperone Cdc37; N-terminally processed; CDC37; CDC37A
 Product Gene Name   

CDC37 blocking peptide

[Similar Products]
 Product Synonym Gene Name    CDC37A [Similar Products]
 Antibody/Peptide Pairs    CDC37 peptide (MBS9227948) is used for blocking the activity of CDC37 antibody (MBS9203203)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605065
 3D Structure    ModBase 3D Structure for Q16543
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 Specificity    The synthetic peptide sequence used to generate the antibody was selected from the Center region of human CDC37. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
 Form/Format    Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
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 Cellular Location    Cytoplasm.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of CDC37 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CDC37 blocking peptide

   Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.
NCBI/Uniprot data below describe general gene information for CDC37. It may not necessarily be applicable to this product.
 NCBI GI #    21542000
 NCBI GeneID    11140
 NCBI Accession #    Q16543.1 [Other Products]
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 UniProt Primary Accession #    Q16543 [Other Products]
 UniProt Secondary Accession #    Q53YA2 [Other Products]
 UniProt Related Accession #    Q16543 [Other Products]
 Molecular Weight    44,468 Da
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 NCBI Official Full Name    Hsp90 co-chaperone Cdc37
 NCBI Official Synonym Full Names    cell division cycle 37
 NCBI Official Symbol    CDC37 [Similar Products]
 NCBI Official Synonym Symbols   
P50CDC37
[Similar Products]
 NCBI Protein Information    hsp90 co-chaperone Cdc37
 UniProt Protein Name    Hsp90 co-chaperone Cdc37
 UniProt Synonym Protein Names   
Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37
 Protein Family    Hsp90 co-chaperone
 UniProt Gene Name    CDC37 [Similar Products]
 UniProt Synonym Gene Names    CDC37A [Similar Products]
 UniProt Entry Name    CDC37_HUMAN
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 NCBI Summary for CDC37    The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CDC37    CDC37: a molecular chaperone that functions in cell signal transduction. Forms complexes with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. Also interacts with androgen receptor. It is thought to play a critical role in directing Hsp90 to its target kinases.

Protein type: Chaperone

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cytoplasm; cytosol

Molecular Function: chaperone binding; heat shock protein binding; kinase binding; protein binding; protein-tyrosine kinase activity; unfolded protein binding

Biological Process: protein folding; protein stabilization; protein targeting; regulation of cyclin-dependent protein kinase activity
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 Research Articles on CDC37    1. Apart from these distinct Cdc37/Hsp90 interfaces, binding of the B-Raf protein kinase to the cochaperone is conserved between mammals and nematodes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CDC37 blocking peptidePathways associated with CDC37 blocking peptide
 Reference Product  PubMed Publications
 CDK4 blocking peptide  >33 publications with CDC37 and CDK4
 SRC blocking peptide  >29 publications with CDC37 and SRC
 CDK6 blocking peptide  >7 publications with CDC37 and CDK6
 HSP90AB1 blocking peptide  >5 publications with CDC37 and HSP90AB1
 EGFR blocking peptide  >4 publications with CDC37 and EGFR
 AKT1 blocking peptide  >3 publications with CDC37 and AKT1
 STK11 blocking peptide  >3 publications with CDC37 and STK11
 LRRK2 blocking peptide  >2 publications with CDC37 and LRRK2
 HSP90AA1 blocking peptide  >2 publications with CDC37 and HSP90AA1
 Products by Pathway  Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Constitutive Signaling By EGFRvIII Pathway antibodies  Constitutive Signaling By EGFRvIII Pathway Diagram
 Constitutive Signaling By Ligand-Responsive EGFR Cancer Variants Pathway antibodies  Constitutive Signaling By Ligand-Responsive EGFR Cancer Variants Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 LKB1 Signaling Events Pathway antibodies  LKB1 Signaling Events Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By EGFR In Cancer Pathway antibodies  Signaling By EGFR In Cancer Pathway Diagram
Diseases associated with CDC37 blocking peptideOrgans/Tissues associated with CDC37 blocking peptide
 Disease Name  Pubmed Publications
 Leukemia Antibodies  >16 publications with CDC37 and Leukemia
 Necrosis Antibodies  >11 publications with CDC37 and Necrosis
 Gastrointestinal Diseases Antibodies  >8 publications with CDC37 and Gastrointestinal Diseases
 Breast Neoplasms Antibodies  >8 publications with CDC37 and Breast Neoplasms
 Inflammation Antibodies  >6 publications with CDC37 and Inflammation
 Pancreatic Neoplasms Antibodies  >6 publications with CDC37 and Pancreatic Neoplasms
 Cell Transformation, Neoplastic Antibodies  >6 publications with CDC37 and Cell Transformation, Neoplastic
 Liver Neoplasms Antibodies  >5 publications with CDC37 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >5 publications with CDC37 and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >5 publications with CDC37 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >14 publications with CDC37 and Blood
 Brain Antibodies  >10 publications with CDC37 and Brain
 Liver Antibodies  >9 publications with CDC37 and Liver
 Lung Antibodies  >8 publications with CDC37 and Lung
 Muscle Antibodies  >8 publications with CDC37 and Muscle
 Bone Antibodies  >7 publications with CDC37 and Bone
 Prostate Antibodies  >6 publications with CDC37 and Prostate
 Embryonic Tissue Antibodies  >6 publications with CDC37 and Embryonic Tissue
 Heart Antibodies  >5 publications with CDC37 and Heart
 Kidney Antibodies  >4 publications with CDC37 and Kidney
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