P35790.3
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,155 Da
NCBI Official Full Name
Choline kinase alpha
NCBI Official Synonym Full Names
choline kinase alpha
NCBI Protein Information
choline kinase alpha
UniProt Protein Name
Choline kinase alpha
UniProt Synonym Protein Names
CHETK-alpha; Ethanolamine kinase (EC:2.7.1.82); EK
UniProt Synonym Gene Names
UniProt Entry Name
CHKA_HUMAN
NCBI Summary for CHKA
The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CHKA
CHKA: Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline. Belongs to the choline/ethanolamine kinase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.7.1.32; Lipid Metabolism - glycerophospholipid; Kinase, other; EC 2.7.1.82
Chromosomal Location of Human Ortholog: 11q13.2
Cellular Component: cytosol
Molecular Function: choline kinase activity; drug binding; ethanolamine kinase activity; signal transducer activity
Biological Process: lipid metabolic process; lipid transport; phosphatidylcholine biosynthetic process; phosphatidylethanolamine biosynthetic process
Research Articles on CHKA
Precautions
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Pathways associated with CHKA blocking peptide
Diseases associated with CHKA blocking peptide
Organs/Tissues associated with CHKA blocking peptide
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