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CHRM3 blocking peptide

Scan QR to view Datasheet Catalog #    MBS9230710 CHRM3 blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CHRM3, Blocking Peptide

 Also Known As   

CHRM3 Blocking Peptide (Center)

 Product Synonym Names    Muscarinic acetylcholine receptor M3; CHRM3
 Product Gene Name   

CHRM3 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    CHRM3 peptide (MBS9230710) is used for blocking the activity of CHRM3 antibody (MBS9217274)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    100100
 3D Structure    ModBase 3D Structure for P20309
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 Specificity    The synthetic peptide sequence is selected from aa 253-264 of HUMAN CHRM3
 Form/Format    Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
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 Cellular Location    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of CHRM3 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for CHRM3 blocking peptide

   The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
NCBI/Uniprot data below describe general gene information for CHRM3. It may not necessarily be applicable to this product.
 NCBI GI #    113125
 NCBI GeneID    1131
 NCBI Accession #    P20309.1 [Other Products]
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 UniProt Primary Accession #    P20309 [Other Products]
 UniProt Secondary Accession #    Q0VAJ8; Q4QRI3; Q5VXY2; Q9HB60 [Other Products]
 UniProt Related Accession #    P20309 [Other Products]
 Molecular Weight    66,128 Da
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 NCBI Official Full Name    Muscarinic acetylcholine receptor M3
 NCBI Official Synonym Full Names    cholinergic receptor muscarinic 3
 NCBI Official Symbol    CHRM3 [Similar Products]
 NCBI Official Synonym Symbols   
HM3; PBS; EGBRS
[Similar Products]
 NCBI Protein Information    muscarinic acetylcholine receptor M3
 UniProt Protein Name    Muscarinic acetylcholine receptor M3
 Protein Family    Muscarinic acetylcholine receptor
 UniProt Gene Name    CHRM3 [Similar Products]
 UniProt Entry Name    ACM3_HUMAN
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 NCBI Summary for CHRM3    The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CHRM3    mAChR M3: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS). EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: integral to plasma membrane; plasma membrane; synapse

Molecular Function: acetylcholine binding; G-protein coupled acetylcholine receptor activity; phosphoinositide phospholipase C activity; protein binding; receptor activity

Biological Process: acetylcholine receptor signaling, muscarinic pathway; cell proliferation; G-protein coupled receptor protein signaling pathway; muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway; muscarinic acetylcholine receptor, phospholipase C activating pathway; nervous system development; protein modification process; regulation of vascular smooth muscle contraction; signal transduction; synaptic transmission, cholinergic

Disease: Abdominal Muscles, Absence Of, With Urinary Tract Abnormality And Cryptorchidism
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 Research Articles on CHRM3    1. results suggest that the autoantibodies against peptides of the second extracellular loop of M3R are not pathogenic in vivo and they are not suitable as biomarkers for pSS diagnosis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to CHRM3 Blocking Peptide (Center)
 Catalog #  Product Name  Catalog #  Product Name
 MBS966305  Recombinant Chicken Muscarinic acetylcholine receptor M3 (CHRM3)  MBS240092  Rabbit Polyclonal to Human CHRM3 / M3
 MBS9217275  CHRM3 Antibody (C-Term)  MBS240007  Rabbit Polyclonal to Human CHRM3 / M3
 MBS7011433  Recombinant Mouse Muscarinic acetylcholine receptor M3 (Chrm3)  MBS2024847  Cholinergic Receptor, Muscarinic 3 (CHRM3) ELISA Kit
 MBS7011435  Recombinant Pig Muscarinic acetylcholine receptor M3 (CHRM3)  MBS451233  Mouse Cholinergic Receptor, Muscarinic 3 (CHRM3) ELISA Kit
 MBS7011432  Recombinant Gorilla gorilla gorilla Muscarinic acetylcholine receptor M3 (CHRM3)  MBS7011430  Recombinant Bovine Muscarinic acetylcholine receptor M3 (CHRM3)
Pathways associated with CHRM3 blocking peptideDiseases associated with CHRM3 blocking peptide
 Products by Pathway  Pathway Diagram
 Acetylcholine Regulates Insulin Secretion Pathway antibodies  Acetylcholine Regulates Insulin Secretion Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >7 publications with CHRM3 and Nervous System Diseases
 Inflammation Antibodies  >6 publications with CHRM3 and Inflammation
 Disease Models, Animal Antibodies  >3 publications with CHRM3 and Disease Models, Animal
 Seizures Antibodies  >2 publications with CHRM3 and Seizures
 Pain Antibodies  >2 publications with CHRM3 and Pain
 Prune Belly Syndrome Antibodies  >2 publications with CHRM3 and Prune Belly Syndrome
 Depressive Disorder Antibodies  >2 publications with CHRM3 and Depressive Disorder
 Drug-Related Side Effects and Adverse Reactions Antibodies  >2 publications with CHRM3 and Drug-Related Side Effects and Adverse Reactions
 Neurobehavioral Manifestations Antibodies  >2 publications with CHRM3 and Neurobehavioral Manifestations
 Fibrosis Antibodies  >2 publications with CHRM3 and Fibrosis
Organs/Tissues associated with CHRM3 blocking peptide
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with CHRM3 and Brain
 Prostate Antibodies  >3 publications with CHRM3 and Prostate
 Eye Antibodies  >3 publications with CHRM3 and Eye
 Heart Antibodies  >2 publications with CHRM3 and Heart
 Bone Antibodies  >1 publications with CHRM3 and Bone
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