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CHRNA1 blocking peptide

Scan QR to view Datasheet Catalog #    MBS8236826 CHRNA1 blocking peptide
Unit / Price
1 mg  /  $160 +1 FREE 8GB USB
5 mg  /  $305 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CHRNA1, Blocking Peptide

★Popular Item★
 Also Known As   

CHRNA1 Blocking Peptide

 Product Synonym Names    ACHRA; CHNRA; Acetylcholine receptor subunit alpha
 Product Gene Name   

CHRNA1 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    CHRNA1 peptide (MBS8236826) is used for blocking the activity of CHRNA1 antibody (MBS8224610)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    100690
 3D Structure    ModBase 3D Structure for P02708
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 Host    Synthetic
 Species Reactivity    Human, Mouse, Rat, Bovine, Dog
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 Purity/Purification    >85%
 Form/Format    Lyophilized powder
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 Quality Control    The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
 Directions for Use    Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Other Notes    Small volumes of CHRNA1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CHRNA1 blocking peptide

   The peptide is used to block Anti-CHRNA1 Antibody reactivity.
 Applications Tested/Suitable for CHRNA1 blocking peptide   

Blocking (BL)

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NCBI/Uniprot data below describe general gene information for CHRNA1. It may not necessarily be applicable to this product.
 NCBI GI #    4557457
 NCBI GeneID    1134
 NCBI Accession #    NP_000070.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000079.3 [Other Products]
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 UniProt Primary Accession #    P02708 [Other Products]
 UniProt Secondary Accession #    B4DRV6; D3DPE8 [Other Products]
 UniProt Related Accession #    P02708 [Other Products]
 Molecular Weight    51,839 Da
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 NCBI Official Full Name    acetylcholine receptor subunit alpha isoform b
 NCBI Official Synonym Full Names    cholinergic receptor, nicotinic, alpha 1 (muscle)
 NCBI Official Symbol    CHRNA1 [Similar Products]
 NCBI Official Synonym Symbols   
ACHRA; ACHRD; CHRNA; CMS1A; CMS1B; CMS2A; FCCMS; SCCMS
[Similar Products]
 NCBI Protein Information    acetylcholine receptor subunit alpha
 UniProt Protein Name    Acetylcholine receptor subunit alpha
 Protein Family    Acetylcholine receptor
 UniProt Gene Name    CHRNA1 [Similar Products]
 UniProt Synonym Gene Names    ACHRA; CHNRA [Similar Products]
 UniProt Entry Name    ACHA_HUMAN
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 NCBI Summary for CHRNA1    The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2012]
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 UniProt Comments for CHRNA1    nAChRA1: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in CHRNA1 are a cause of multiple pterygium syndrome lethal type (MUPSL). Multiple pterygia are found infrequently in children with arthrogryposis and in fetuses with fetal akinesia syndrome. In lethal multiple pterygium syndrome there is intrauterine growth retardation, multiple pterygia, and flexion contractures causing severe arthrogryposis and fetal akinesia. Subcutaneous edema can be severe, causing fetal hydrops with cystic hygroma and lung hypoplasia. Oligohydramnios and facial anomalies are frequent. The alpha subunit is the main focus for antibody binding in myasthenia gravis. Myasthenia gravis is characterized by sporadic muscular fatigability and weakness, occurring chiefly in muscles innervated by cranial nerves, and characteristically improved by cholinesterase-inhibiting drugs. Defects in CHRNA1 are a cause of congenital myasthenic syndrome slow-channel type (SCCMS). SCCMS is the most common congenital myasthenic syndrome. Congenital myasthenic syndromes are characterized by muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. SCCMS is caused by kinetic abnormalities of the AChR, resulting in prolonged endplate currents and prolonged AChR channel opening episodes. Defects in CHRNA1 are a cause of congenital myasthenic syndrome fast-channel type (FCCMS). FCCMS is a congenital myasthenic syndrome characterized by kinetic abnormalities of the AChR. In most cases, FCCMS is due to mutations that decrease activity of the AChR by slowing the rate of opening of the receptor channel, speeding the rate of closure of the channel, or decreasing the number of openings of the channel during ACh occupancy. The result is failure to achieve threshold depolarization of the endplate and consequent failure to fire an action potential. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 1/CHRNA1 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, cation; Membrane protein, integral; Channel, ligand-gated; Receptor, misc.; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; cell surface; plasma membrane; neuromuscular junction; cell junction

Molecular Function: acetylcholine receptor activity; ion channel activity; nicotinic acetylcholine-activated cation-selective channel activity; acetylcholine binding

Biological Process: muscle maintenance; skeletal muscle contraction; synaptic transmission; regulation of membrane potential; transport; neuromuscular process; generation of action potential; neuromuscular synaptic transmission; skeletal muscle growth; signal transduction; musculoskeletal movement; neuromuscular junction development

Disease: Myasthenic Syndrome, Congenital, Fast-channel; Multiple Pterygium Syndrome, Lethal Type; Myasthenic Syndrome, Congenital, Slow-channel
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 Research Articles on CHRNA1    1. show that AON complementary to the 5' splice site of the exon was the most effective at exon skipping of the minigene with causative mutations, as well as endogenous wild-type CHRNA1
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CHRNA1 blocking peptidePathways associated with CHRNA1 blocking peptide
 Reference Product  PubMed Publications
 CHRND blocking peptide  >11 publications with CHRNA1 and CHRND
 RAPSN blocking peptide  >10 publications with CHRNA1 and RAPSN
 AGRN blocking peptide  >2 publications with CHRNA1 and AGRN
 CHRM1 blocking peptide  >2 publications with CHRNA1 and CHRM1
 Products by Pathway  Pathway Diagram
 Acetylcholine Binding And Downstream Events Pathway antibodies  Acetylcholine Binding And Downstream Events Pathway Diagram
 Activation Of Nicotinic Acetylcholine Receptors Pathway antibodies  Activation Of Nicotinic Acetylcholine Receptors Pathway Diagram
 Effects Of Botulinum Toxin Pathway antibodies  Effects Of Botulinum Toxin Pathway Diagram
 ErbB2/ErbB3 Signaling Events Pathway antibodies  ErbB2/ErbB3 Signaling Events Pathway Diagram
 Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway antibodies  Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway Diagram
 Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway antibodies  Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram
Diseases associated with CHRNA1 blocking peptideOrgans/Tissues associated with CHRNA1 blocking peptide
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >5 publications with CHRNA1 and Lung Diseases
 MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE Antibodies  >5 publications with CHRNA1 and MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE
 Cardiovascular Diseases Antibodies  >3 publications with CHRNA1 and Cardiovascular Diseases
 Edema Antibodies  >3 publications with CHRNA1 and Edema
 Inflammation Antibodies  >3 publications with CHRNA1 and Inflammation
 Disease Models, Animal Antibodies  >2 publications with CHRNA1 and Disease Models, Animal
 Myasthenic Syndrome, Congenital, Fast-Channel Antibodies  >2 publications with CHRNA1 and Myasthenic Syndrome, Congenital, Fast-Channel
 Fetal Death Antibodies  >1 publications with CHRNA1 and Fetal Death
 Atherosclerosis Antibodies  >1 publications with CHRNA1 and Atherosclerosis
 Hyperplasia Antibodies  >1 publications with CHRNA1 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >28 publications with CHRNA1 and Muscle
 Thymus Antibodies  >5 publications with CHRNA1 and Thymus
 Brain Antibodies  >3 publications with CHRNA1 and Brain
 Skin Antibodies  >2 publications with CHRNA1 and Skin
 Heart Antibodies  >1 publications with CHRNA1 and Heart
 Liver Antibodies  >1 publications with CHRNA1 and Liver
 Vascular Antibodies  >1 publications with CHRNA1 and Vascular
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