Q9UBD9.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,087 Da
NCBI Official Full Name
Cardiotrophin-like cytokine factor 1
NCBI Official Synonym Full Names
cardiotrophin-like cytokine factor 1
NCBI Official Synonym Symbols
CLC; NR6; BSF3; NNT1; BSF-3; CISS2; NNT-1 [Similar Products]
NCBI Protein Information
cardiotrophin-like cytokine factor 1
UniProt Protein Name
Cardiotrophin-like cytokine factor 1
UniProt Synonym Protein Names
B-cell-stimulating factor 3; BSF-3; Novel neurotrophin-1; NNT-1
UniProt Synonym Gene Names
UniProt Entry Name
CLCF1_HUMAN
NCBI Summary for CLCF1
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
UniProt Comments for CLCF1
CLCF1: Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor. Defects in CLCF1 are the cause of cold-induced sweating syndrome type 2 (CISS2). Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high- arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Cytokine; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 11q13.3
Cellular Component: extracellular region
Molecular Function: ciliary neurotrophic factor receptor binding; cytokine activity; growth factor activity; protein binding; protein heterodimerization activity; receptor binding
Biological Process: B cell differentiation; cell surface receptor linked signal transduction; JAK-STAT cascade; negative regulation of neuron apoptosis; positive regulation of astrocyte differentiation; positive regulation of B cell proliferation; positive regulation of cell proliferation; positive regulation of immunoglobulin production; positive regulation of isotype switching to IgE isotypes; positive regulation of tyrosine phosphorylation of Stat3 protein
Disease: Cold-induced Sweating Syndrome 2
Research Articles on CLCF1
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Pathways associated with CLCF1 blocking peptide
Diseases associated with CLCF1 blocking peptide
Organs/Tissues associated with CLCF1 blocking peptide
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