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CLCF1 blocking peptide

Scan QR to view Datasheet Catalog #    MBS9223749 CLCF1 blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Product Name   

CLCF1, Blocking Peptide

★Popular Item★
 Also Known As   

CLCF1 Antibody (N-term) Blocking Peptide

 Product Synonym Names    Cardiotrophin-like cytokine factor 1; B-cell-stimulating factor 3; BSF-3; Novel neurotrophin-1; NNT-1; CLCF1; BSF3; CLC; NNT1
 Product Gene Name   

CLCF1 blocking peptide

[Similar Products]
 Product Synonym Gene Name    BSF3; CLC; NNT1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607672
 3D Structure    ModBase 3D Structure for Q9UBD9
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 Form/Format    Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
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 Cellular Location    Secreted.
 Tissue Location    Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of CLCF1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CLCF1 blocking peptide

   Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor.
NCBI/Uniprot data below describe general gene information for CLCF1. It may not necessarily be applicable to this product.
 NCBI GI #    56404673
 NCBI GeneID    23529
 NCBI Accession #    Q9UBD9.1 [Other Products]
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 UniProt Primary Accession #    Q9UBD9 [Other Products]
 UniProt Secondary Accession #    Q6NZA4; B4DNT4 [Other Products]
 UniProt Related Accession #    Q9UBD9 [Other Products]
 Molecular Weight    24,087 Da
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 NCBI Official Full Name    Cardiotrophin-like cytokine factor 1
 NCBI Official Synonym Full Names    cardiotrophin-like cytokine factor 1
 NCBI Official Symbol    CLCF1 [Similar Products]
 NCBI Official Synonym Symbols   
CLC; NR6; BSF3; NNT1; BSF-3; CISS2; NNT-1
[Similar Products]
 NCBI Protein Information    cardiotrophin-like cytokine factor 1
 UniProt Protein Name    Cardiotrophin-like cytokine factor 1
 UniProt Synonym Protein Names   
B-cell-stimulating factor 3; BSF-3; Novel neurotrophin-1; NNT-1
 Protein Family    Cardiotrophin-like cytokine factor
 UniProt Gene Name    CLCF1 [Similar Products]
 UniProt Synonym Gene Names    BSF3; CLC; NNT1; BSF-3; NNT-1 [Similar Products]
 UniProt Entry Name    CLCF1_HUMAN
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 NCBI Summary for CLCF1    This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
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 UniProt Comments for CLCF1    CLCF1: Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor. Defects in CLCF1 are the cause of cold-induced sweating syndrome type 2 (CISS2). Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high- arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cytokine; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: extracellular region

Molecular Function: ciliary neurotrophic factor receptor binding; cytokine activity; growth factor activity; protein binding; protein heterodimerization activity; receptor binding

Biological Process: B cell differentiation; cell surface receptor linked signal transduction; JAK-STAT cascade; negative regulation of neuron apoptosis; positive regulation of astrocyte differentiation; positive regulation of B cell proliferation; positive regulation of cell proliferation; positive regulation of immunoglobulin production; positive regulation of isotype switching to IgE isotypes; positive regulation of tyrosine phosphorylation of Stat3 protein

Disease: Cold-induced Sweating Syndrome 2
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 Research Articles on CLCF1    1. Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CLCF1 blocking peptideDiseases associated with CLCF1 blocking peptide
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL-6-type Cytokine Receptor Ligand Interactions Pathway antibodies  IL-6-type Cytokine Receptor Ligand Interactions Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-6 Family Signaling Pathway antibodies  Interleukin-6 Family Signaling Pathway Diagram
 Signaling By Interleukins Pathway antibodies  Signaling By Interleukins Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >2 publications with CLCF1 and Cardiovascular Diseases
 Seizures Antibodies  >2 publications with CLCF1 and Seizures
 Inflammation Antibodies  >2 publications with CLCF1 and Inflammation
 Lung Diseases Antibodies  >1 publications with CLCF1 and Lung Diseases
 Lung Neoplasms Antibodies  >1 publications with CLCF1 and Lung Neoplasms
 Fibrosis Antibodies  >1 publications with CLCF1 and Fibrosis
 Kidney Diseases Antibodies  >1 publications with CLCF1 and Kidney Diseases
 Necrosis Antibodies  >1 publications with CLCF1 and Necrosis
Organs/Tissues associated with CLCF1 blocking peptide
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >5 publications with CLCF1 and Nerve
 Brain Antibodies  >3 publications with CLCF1 and Brain
 Skin Antibodies  >3 publications with CLCF1 and Skin
 Liver Antibodies  >1 publications with CLCF1 and Liver
 Bone Marrow Antibodies  >1 publications with CLCF1 and Bone Marrow
 Bone Antibodies  >1 publications with CLCF1 and Bone
 Lung Antibodies  >1 publications with CLCF1 and Lung
 Kidney Antibodies  >1 publications with CLCF1 and Kidney
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