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CR2 blocking peptide

Scan QR to view Datasheet Catalog #    MBS9226459 CR2 blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CR2, Blocking Peptide

★Popular Item★
 Also Known As   

CR2 Antibody (C-term) Blocking Peptide

 Product Synonym Names    Complement receptor type 2; Cr2; Complement C3d receptor; Epstein-Barr virus receptor; EBV receptor; CD21; CR2; C3DR
 Product Gene Name   

CR2 blocking peptide

[Similar Products]
 Product Synonym Gene Name    C3DR [Similar Products]
 Antibody/Peptide Pairs    CR2 peptide (MBS9226459) is used for blocking the activity of CR2 antibody (MBS9209801)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    120650
 3D Structure    ModBase 3D Structure for P20023
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 Clone Number    90504056
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 Specificity    The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human CR2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
 Form/Format    Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
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 Cellular Location    Membrane; Single-pass type I membrane protein
 Tissue Location    Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen
 Function    Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of CR2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CR2 blocking peptide

   CR2 is a membrane protein , which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes.
NCBI/Uniprot data below describe general gene information for CR2. It may not necessarily be applicable to this product.
 NCBI GI #    215273962
 NCBI GeneID    1380
 NCBI Accession #    P20023.2 [Other Products]
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 UniProt Primary Accession #    P20023 [Other Products]
 UniProt Secondary Accession #    Q13866; Q14212; Q53EL2; Q5BKT9; Q5SR46; Q5SR48; C9JHD2 [Other Products]
 UniProt Related Accession #    P20023 [Other Products]
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 NCBI Official Full Name    Complement receptor type 2
 NCBI Official Synonym Full Names    complement component 3d receptor 2
 NCBI Official Symbol    CR2 [Similar Products]
 NCBI Official Synonym Symbols   
CR; C3DR; CD21; CVID7; SLEB9
[Similar Products]
 NCBI Protein Information    complement receptor type 2
 UniProt Protein Name    Complement receptor type 2
 UniProt Synonym Protein Names   
Complement C3d receptor; Epstein-Barr virus receptor; EBV receptor; CD_antigen: CD21
 Protein Family    Complement receptor
 UniProt Gene Name    CR2 [Similar Products]
 UniProt Synonym Gene Names    C3DR; Cr2; EBV receptor [Similar Products]
 UniProt Entry Name    CR2_HUMAN
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 NCBI Summary for CR2    This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
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 UniProt Comments for CR2    CR2: Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation. Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Defects in CR2 are the cause of immunodeficiency, common variable, type 7 (CVID7). A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. Belongs to the receptors of complement activation (RCA) family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: receptor complex

Molecular Function: complement binding; DNA binding; protein homodimerization activity

Biological Process: B cell differentiation; B cell proliferation

Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 7; Systemic Lupus Erythematosus, Susceptibility To, 9
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 Research Articles on CR2    1. These data suggest that rs1876453 in CR2 has long-range effects on gene regulation that decrease susceptibility to systemic lupus erythematosus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CR2 blocking peptideDiseases associated with CR2 blocking peptide
 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >58 publications with CR2 and Inflammation
 Disease Models, Animal Antibodies  >51 publications with CR2 and Disease Models, Animal
 Lupus Erythematosus, Systemic Antibodies  >43 publications with CR2 and Lupus Erythematosus, Systemic
 Immunologic Deficiency Syndromes Antibodies  >36 publications with CR2 and Immunologic Deficiency Syndromes
 Necrosis Antibodies  >31 publications with CR2 and Necrosis
 Liver Diseases Antibodies  >17 publications with CR2 and Liver Diseases
 Lung Diseases Antibodies  >16 publications with CR2 and Lung Diseases
 Neoplasms, Experimental Antibodies  >14 publications with CR2 and Neoplasms, Experimental
 Skin Diseases Antibodies  >13 publications with CR2 and Skin Diseases
 Sarcoma Antibodies  >13 publications with CR2 and Sarcoma
Organs/Tissues associated with CR2 blocking peptide
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >685 publications with CR2 and Blood
 Spleen Antibodies  >64 publications with CR2 and Spleen
 Kidney Antibodies  >53 publications with CR2 and Kidney
 Lymph Node Antibodies  >46 publications with CR2 and Lymph Node
 Brain Antibodies  >38 publications with CR2 and Brain
 Liver Antibodies  >35 publications with CR2 and Liver
 Tonsil Antibodies  >25 publications with CR2 and Tonsil
 Lymph Antibodies  >25 publications with CR2 and Lymph
 Vascular Antibodies  >24 publications with CR2 and Vascular
 Thymus Antibodies  >18 publications with CR2 and Thymus
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